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Please use this identifier to cite or link to this item:
http://arca.icict.fiocruz.br/handle/icict/1749
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| Title: | Mechanisms involved in the antinociceptive effects of 7-Hydroxycoumarin |
| Authors: | Lima, Flávia Oliveira de
Nonato, Fabiana Regina
Couto, Ricardo David
Barbosa Filho, José Maria
Nunes, Xirley Pereira
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora |
| Affilliation: | Centro de Pesquisa Gonçalo Moniz |
| Keywords in English: | 7-hydroxycoumarin
Coumarins
Antinociceptives
Pain |
| Keywords in Portuguese: | Umbeliferonas
7-Hidroxicumarinas
Antinoceceptivos
Inflamação |
| DeCS Keywords: | Umbeliferonas
Inflamação/PC
Dor/TH
Cumarinicos
Plantas medicinais |
| Issue Date: | 18-Mar-2011 |
| Source: | LIMA, Flávia Oliveira de et al. Mechanisms involved in the antinociceptive effects of 7-Hydroxycoumarin. Journal of Natural Products, v. 74, n. 4, p. 596-602, 2011. |
| Abstract: | 7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund’s adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E2 (PGE2), suggesting that it acts upstream of PGE2. Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-R and IL-1β) and the production of PGE2, a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE2 production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain. |
| Appears in Collections: | CPqGM - Artigos de Periódicos
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