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Please use this identifier to cite or link to this item:
http://arca.icict.fiocruz.br/handle/icict/1853
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| Title: | Research needs for Chagas disease prevention |
| Authors: | Abad-Franch, Fernando
Santos, Walter S
Schofield, Christopher J. |
| Affilliation: | Instituto Leônidas e Maria Deane – Fiocruz AmazoniaManaus, Amazonas, Brazil
Instituto Leônidas e Maria Deane – Fiocruz AmazoniaManaus, Amazonas, Brazil
London School of Hygiene and Tropical Medicine, London |
| Keywords in English: | Chagas disease
Prevention
Patient care
Triatominae
Control
Research |
| Issue Date: | 2010 |
| Source: | Acta Tropical V. 115, n.1/2, p.44-54, jul./aug. 2010 |
| Abstract: | Wepresent an overview of the two main strategies for the primary (vector control) and secondary (patient
care) prevention of Chagas disease (CD). We identify major advances, knowledge gaps, and key research
needs in both areas. Improved specific chemotherapy, including more practical formulations (e.g., paediatric)
or combinations of existing drugs, and a better understanding of pathogenesis, including the
relative weights of parasite and host genetic makeup, are clearly needed. Regarding CD vectors, we find
that only about 10–20% of published papers on triatomines deal directly with disease control. We pinpoint
the pitfalls of the current consensus on triatomine systematics, particularly within the Triatomini,
and suggest how some straightforward sampling and analytical strategies would improve research on
vector ecology, naturally leading to sounder control-surveillance schemes. We conclude that sustained
research on CD prevention is still crucial. In the past, it provided not only the know-how, but also the
critical mass of scientists needed to foster and consolidate CD prevention programmes; in the future,
both patient care and long-term vector control would nonetheless benefit from more sharply focused,
problem-oriented research. |
| Appears in Collections: | ILMD - Artigos de Periódicos
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