Author | Silva, Patrícia Santiago | |
Author | Grinsztejn, Beatriz | |
Author | Friedman, Ruth Khalili | |
Author | Cunha, Cynthia Braga da Cunha | |
Author | Coelho, Lara Esteves | |
Author | Luz, Paula Mendes | |
Author | Oliveira, Albanita Viana de | |
Author | Moreira, Ronaldo Ismério | |
Author | Cardoso, Sandra Wagner | |
Author | Santos, Valdiléa Gonçalves Veloso dos | |
Author | Suassuna, José Hermógenes Rocco | |
Access date | 2015-05-11T18:07:25Z | |
Available date | 2015-05-11T18:07:25Z | |
Document date | 2014 | |
Citation | SILVA, Patrícia Santiago et al. Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country. Plos One, v. 9, n. 4, p. 1-7, Apr. 2014. | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/10284 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | Screening for decreased glomerular filtration rate and associated risk factors in a cohort of HIV-infected patients in a middle-income country | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0093748 | |
Abstract | With the introduction of combined active antiretroviral therapy and the improved survival of HIV-infected patients,
degenerative diseases and drug toxicity have emerged as long-term concerns. We studied the prevalence of decreased
glomerular filtration rate (GFR) and associated risk factors in a cohort of HIV-infected patients from a middle-income
country. Our cross-sectional study included all adult patients who attended an urban outpatient clinic in 2008. GFR was
estimated using the CKD-EPI equation. The prevalence ratio (PR) of decreased GFR (defined as ,60 mL/min/1.73 m2) was
estimated using generalizing linear models assuming a Poisson distribution. We analyzed data from 1,970 patients, of which
82.9% had been exposed to ART. A total of 249 patients (12.6%) had a GFR between 60 and 89 mL/min/1.73 m2, 3.1% had a
GFR between 30 and 59, 0.3% had a GFR between 15 and 29, and 0.4% had a GFR ,15. Decreased GFR was found in only 74
patients (3.8%). In the multivariate regression model, the factors that were independently associated with a GFR below
60 mL/min/1.73 m2 were as follows: age $50 years (PR = 3.4; 95% CI: 1.7–6.8), diabetes (PR = 2.0; 95% CI: 1.2–3.4),
hypertension (PR = 2.0; 95% CI: 1.3–3.2), current CD4+ cell count ,350 cells/mm3 (PR = 2.1; 95% CI: 1.3–3.3), past exposure
to tenofovir (PR = 4.7; 95% CI: 2.3–9.4) and past exposure to indinavir (PR = 1.7; 95% CI: 1.0–2.8). As in high-income countries,
CKD was the predominant form of kidney involvement among HIV-infected individuals in our setting. The risk factors
associated with decreased glomerular filtration were broad and included virus-related factors as well as degenerative and
nephrotoxic factors. Despite the potential for nephrotoxicity associated with some antiretroviral drugs, in the short-term,
advanced chronic renal disease remains very rare. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasi | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Acquired Immunodeficiency Syndrome | pt_BR |
Subject | Glomerular filtration rate | pt_BR |
Subject | Highly active antiretroviral therapy | pt_BR |
Subject | Statistical analysis | pt_BR |
DeCS | Síndrome de Imunodeficiência Adquirida | pt_BR |
DeCS | Taxa de filtração glomerular | pt_BR |
DeCS | Terapia antirretroviral de alta atividade | pt_BR |
DeCS | Análise estatística | pt_BR |
e-ISSN | 1932-6203 | |