Author | Bray, Daniel P. | |
Author | Carter, Vicky | |
Author | Alves, Graziella Borges | |
Author | Brazil, Reginaldo P. | |
Author | Bandi, Krishna K. | |
Author | Hamilton, James G. C. | |
Access date | 2015-05-15T13:16:46Z | |
Available date | 2015-05-15T13:16:46Z | |
Document date | 2014 | pt_BR |
Citation | BRAY, Daniel P. et al. Synthetic Sex Pheromone in a Long-Lasting Lure Attracts the Visceral Leishmaniasis Vector, Lutzomyia longipalpis, for up to 12 Weeks in Brazil. PLOS Neglected Tropical Diseases, v.8, n.3, 9p, 2014. | pt_BR |
ISSN | 1935-2735 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/10339 | |
Language | eng | pt_BR |
Publisher | Plos One | pt_BR |
Rights | open access | pt_BR |
Title | Synthetic Sex Pheromone in a Long-Lasting Lure Attracts the Visceral Leishmaniasis Vector, Lutzomyia longipalpis, for up to 12 Weeks in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0002723 | pt_BR |
Abstract | Current control methodologies have not prevented the spread of visceral leishmaniasis (VL) across Brazil. Here, we describe
the development of a new tool for controlling the sand fly vector of the disease: a long-lasting lure, which releases a
synthetic male sex pheromone, attractive to both sexes of Lutzomyia longipalpis. This device could be used to improve the
effectiveness of residual insecticide spraying as a means of sand fly control, attracting L. longipalpis to insecticide-treated
animal houses, where they could be killed in potentially large numbers over a number of weeks. Different lure designs
releasing the synthetic pheromone (6)-9-methylgermacrene-B (CAS 183158-38-5) were field-tested in Arac¸atuba, Sa˜o Paulo
(SP). Experiments compared numbers of sand flies caught overnight in experimental chicken sheds with pheromone lures,
to numbers caught in control sheds without pheromone. Prototype lures, designed to last one night, were first used to
confirm the attractiveness of the pheromone in SP, and shown to attract significantly more flies to test sheds than controls.
Longer-lasting lures were tested when new, and at fortnightly intervals. Lures loaded with 1 mg of pheromone did not
attract sand flies for more than two weeks. However, lures loaded with 10 mg of pheromone, with a releasing surface of
15 cm2 or 7.5 cm2, attracted female L. longipalpis for up to ten weeks, and males for up to twelve weeks. Approximately five
times more sand flies were caught with 7.5 cm2 10 mg lures when first used than occurred naturally in non-experimental
chicken resting sites. These results demonstrate that these lures are suitably long-lasting and attractive for use in sand fly
control programmes in SP. To our knowledge, this is the first sex pheromone-based technology targeting an insect vector of
a neglected human disease. Further studies should explore the general applicability of this approach for combating other
insect-borne diseases. | pt_BR |
Affilliation | Keele University. Institute for Science and Technology in Medicine. Centre for Applied Entomology and Parasitology. Keele, Staffordshire, UK. | pt_BR |
Affilliation | Keele University. Institute for Science and Technology in Medicine. Centre for Applied Entomology and Parasitology. Keele, Staffordshire, UK. | pt_BR |
Affilliation | Keele University. Institute for Science and Technology in Medicine. Centre for Applied Entomology and Parasitology. Keele, Staffordshire, UK. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Keele University. Institute for Science and Technology in Medicine. Centre for Applied Entomology and Parasitology. Keele, Staffordshire, UK. | pt_BR |
Affilliation | Keele University. Institute for Science and Technology in Medicine. Centre for Applied Entomology and Parasitology. Keele, Staffordshire, UK. | pt_BR |
Subject | Visceral Leishmaniasis | pt_BR |
Subject | Lutzomyia longipalpis | pt_BR |
Subject | Brazil | pt_BR |
Subject | Synthetic Sex Pheromone | pt_BR |
xmlui.metadata.dc.subject.ods | 05 Igualdade de gênero | |