Author | Dutra, Lívia Macedo | |
Author | Bomfim, Larissa Mendes | |
Author | Rocha, Suellen Laila A. | |
Author | Nepel, Angelita | |
Author | Soares, Milena Botelho Pereira | |
Author | Barison, Andersson | |
Author | Costa, Emmanoel Vilaça | |
Author | Bezerra, Daniel Pereira | |
Access date | 2015-05-19T19:36:45Z | |
Available date | 2015-05-19T19:36:45Z | |
Document date | 2014 | |
Citation | DUTRA, L. M. et al. ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. Bioorganic & Medicinal Chemistry Letters, v. 24, n. 15, p. 3315-3320, 2014. | pt_BR |
ISSN | 1464-3405 | |
URI | https://www.arca.fiocruz.br/handle/icict/10437 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation. | pt_BR |
Type | Article | pt_BR |
DOI | dx.doi.org/10.1016/j.bmcl.2014.06.005 | |
Abstract | This work describes a novel ent-kaurane diterpene, ent-3ß-hydroxy-kaur-16-en-19-al along with five known ent-kaurane diterpenes, ent-3ß,19-dihydroxy-kaur-16-eno, ent-3ß-hydroxy-kaur-16-eno, ent-3ß-acetoxy-kaur-16-eno, ent-3ß-hydroxy-kaurenoic acid and kaurenoic acid, as well as caryophyllene oxide, humulene epoxide II, ß-sitosterol, stigmasterol and campesterol from the stem bark of Annona vepretorum Mart. (Annonaceae). Cytotoxic activities towards tumor B16-F10, HepG2, K562 and HL60 and non-tumor PBMC cell lines were evaluated for ent-kaurane diterpenes. Among them, ent-3ß-hydroxy-kaur-16-en-19-al was the most active compound with higher cytotoxic effect over K562 cell line (IC50 of 2.49 µg/mL) and lower over B16-F10 cell line (IC50 of 21.02 µg/mL). | pt_BR |
Affilliation | Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Chemistry. Itabaiana, SE, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Annona vepretorum | pt_BR |
Subject | Annonaceae | pt_BR |
Subject | ent-Kaurane diterpenes | pt_BR |
Subject | Cytotoxicity | pt_BR |
DeCS | Annonaceae/química | pt_BR |
DeCS | Antineoplásicos Fitogênicos/farmacologia | pt_BR |
DeCS | Diterpenos de Caurano/farmacologia | pt_BR |
DeCS | Leucócitos Mononucleares/efeitos de drogas | pt_BR |
DeCS | Casca de Planta/química | pt_BR |
DeCS | Caules de Planta/química | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Antineoplásicos Fitogênicos/química | pt_BR |
DeCS | Linhagem Celular Tumoral | pt_BR |
DeCS | Proliferação de Células/efeitos de drogas | pt_BR |
DeCS | Diterpenos de Caurano/isolamento & purificação | pt_BR |
DeCS | Relação Dose-Resposta a Droga | pt_BR |
DeCS | Ensaios de Seleção de Medicamentos Antitumorais | pt_BR |
DeCS | Células HL-60 | pt_BR |
DeCS | Células K562 | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Relação Estrutura-Atividade | pt_BR |