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Autor | Guimarães, Adriana Gibara | |
Autor | Scotti, Luciana | |
Autor | Scotti, Marcus Tullius | |
Autor | Mendonça Júnior, Francisco Jaime Bezerra | |
Autor | Melo, Nayara Stephanie Resende | |
Autor | Alves, Rafael dos Santos | |
Autor | De Lucca Júnior, Waldecy | |
Autor | Bezerra, Daniel Pereira | |
Autor | Gelain, Daniel Pens | |
Autor | Quintans Júnior, Lucindo José | |
Fecha de acceso | 2015-05-20T14:28:54Z | |
Fecha de disponibilización | 2015-05-20T14:28:54Z | |
Fecha de publicación | 2014 | |
Referencia | GUIMARÃES, A. G. et al. Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. Life Science, v. 116, n. 1, p. 8-15, 2014. | pt_BR |
ISSN | 1879-0631 | |
URI | https://www.arca.fiocruz.br/handle/icict/10438 | |
Idioma | eng | pt_BR |
Editor | Elsevier | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | dx.doi.org/10.1016/j.lfs.2014.08.020 | |
Resumen en Inglés | AIMS: The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS: Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical sensitivity (von Frey), spontaneous and palpation-induced nociception, limb use and tumor growth on alternate days. CARV effects on the central nervous system were evaluated through immunofluorescence for Fos protein. Molecular docking studies also were performed to evaluate intermolecular interactions of the carvacrol and muscimol, as ligands of interleukin-10 and GABAA receptors. KEY FINDINGS: CARV was able to significantly reduce mechanical hyperalgesia and spontaneous and palpation-induced nociception, improve use paw, decrease the number of positively marked neurons in lumbar spinal cord and activate periaqueductal gray, nucleus raphe magnus and locus coeruleus. CARV also caused significant decreased tumor growth. Docking studies showed favorable interaction overlay of the CARV with IL-10 and GABAA. SIGNIFICANCE: Together, these results demonstrated that CARV may be an interesting option for the development of new analgesic drugs for the management of cancer pain | pt_BR |
Afiliación | Federal University of Sergipe. Department of Health Education. Lagarto, SE, Brasil | pt_BR |
Afiliación | Federal University of Paraíba. João Pessoa, PB, Brasil | pt_BR |
Afiliación | Federal University of Paraíba. João Pessoa, PB, Brasil | pt_BR |
Afiliación | State University of Paraiba. Laboratory of Synthesis and Drug Delivery. Biological Science Department. João Pessoa, PB, Brasil | pt_BR |
Afiliación | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil | pt_BR |
Afiliación | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil | pt_BR |
Afiliación | Federal University of Sergipe. Department of Morphology,. São Cristóvão, SE, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Afiliación | Federal University of Rio Grande do Sul. Department of Biochemistry. Porto Alegre, RS, Brasil | pt_BR |
Afiliación | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brasil | pt_BR |
Palavras clave en Inglês | Cancer pain | pt_BR |
Palavras clave en Inglês | Hyperalgesia | pt_BR |
Palavras clave en Inglês | Nociception | pt_BR |
Palavras clave en Inglês | Monoterpene | pt_BR |
Palavras clave en Inglês | Carvacrol | pt_BR |
DeCS | Analgésicos/farmacologia | pt_BR |
DeCS | Hiperalgesia/quimioterapia | pt_BR |
DeCS | Monoterpenos/farmacologia | pt_BR |
DeCS | Dor/quimioterapia | pt_BR |
DeCS | Sarcoma 180/complicações | pt_BR |
DeCS | Analgésicos/administração & dosagem | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Relação Dose-Resposta a Droga | pt_BR |
DeCS | Hiperalgesia/etiologia | pt_BR |
DeCS | Interleucina-10/metabolismo | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Simulação de Acoplamento Molecular | pt_BR |
DeCS | Monoterpenos/administração & dosagem | pt_BR |
DeCS | Muscimol/farmacologia | pt_BR |
DeCS | Substância Cinzenta Periaquedutal/efeitos de drogas | pt_BR |
DeCS | Receptores de GABA-A/metabolismo | pt_BR |
DeCS | Sarcoma 180/patologia | pt_BR |
DeCS | Medula Espinal/efeitos de drogas | pt_BR |