Author | Xavier, Flavia Calo de Aquino | |
Author | Prates, Alisio Alves | |
Author | Gurgel, Clarissa Araújo Silva | |
Author | Souza, Tulio Geraldo de | |
Author | Andrade, Rodrigo Guimarães | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Ramalho, Luciana Maria Pedreira | |
Author | Santos, Jean Nunes dos | |
Access date | 2015-05-22T13:24:03Z | |
Available date | 2015-05-22T13:24:03Z | |
Document date | 2014 | |
Citation | XAVIER, f. c. a. et al. Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells. Dermatology Online Journal. v. 20, n. 9, 2014. | pt_BR |
ISSN | 1087-2108 | |
URI | https://www.arca.fiocruz.br/handle/icict/10451 | |
Language | eng | pt_BR |
Publisher | University of California, Davis | pt_BR |
Rights | open access | pt_BR |
Title | Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells | pt_BR |
Type | Article | pt_BR |
Abstract | Lichen sclerosus (LS) is a mucocutaneous disease with uncommon oral involvement. The etiology is not yet well understood, but LS has been associated with autoimmune, genetic, and immunological factors. We report a 47-year-old man with LS that exhibited an asymptomatic white plaque with red patches on the maxillary alveolar mucosa extending to the labial mucosa. He had no other skin disease. Positive immunostaining for tenascin and scarcity of fibronectin suggested extracellular matrix reorganization. Elastin immunostaining indicated a reduction of elastic fibers. Immunoexpression of collagen IV in blood vessels and its absence in the epithelial basement membrane, together with diffuse MMP-9 immunoexpression, suggested altered proteolytic activity. Mast cell staining bordering areas of sclerosis indicated a possible role in the synthesis of collagen. IgG4 positivity in plasma cells suggested a role in the fibrogenesis. This is an unusual presentation of oral LS and we discuss immunohistochemical findings regarding cellular and extracellular matrix components | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Bom Jesus da Lapa, BA, Brasil | pt_BR |
Affilliation | Hospital Aliança. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Português. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Lichen sclerosus et atrophicus | pt_BR |
Subject | Oral cavity | pt_BR |
Subject | Immunohistochemistry | pt_BR |
Subject | Metalloprotein | pt_BR |
Subject | IgG4 | pt_BR |