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IMPAIRMENT OF SYSTEMIC MICROVASCULAR ENDOTHELIAL AND SMOOTH MUSCLE FUNCTION IN INDIVIDUALS WITH EARLY-ONSET CORONARY ARTERY DISEASE: STUDIES WITH LASER SPECKLE CONTRAST IMAGING
Microvascular smooth muscle dysfunction
Microvascular reactivity
Microvascular endothelial dysfunction
Laser speckle
Early-onset coronary artery disease
Autor
Afiliación
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.
Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Objectives The assessment of systemic microvascular
reactivity is currently considered to be critical in the
stratification of cardiovascular risk. In the present study, we
compared skin microvascular function in individuals with
early-onset (premature) coronary artery disease (EOCAD,
n= 30) with that of age-matched and sex-matched healthy
individuals (n =30).
Materials and methods Using laser speckle contrast
imaging, cutaneous blood flow was assessed in the
forearm at rest and during reactivity tests, including
postocclusive reactive hyperemia and the iontophoresis
of acetylcholine or sodium nitroprusside with increasing
currents of 30, 60, 90, 120, 150, and 180 lA for 10-s
intervals spaced 1 min apart. Carotid intima–media
thickness was evaluated using an ultrasound system
and a 7.5MHz ultrasound transducer.
Results The endothelium-dependent skin microvascular
vasodilator responses that were induced by both
acetylcholine and postocclusive reactive hyperemia were
significantly reduced in patients with EOCAD compared
with healthy individuals. The vasodilator responses
that were induced by sodium nitroprusside were also
significantly reduced in individuals with EOCAD. These
systemic microvascular alterations were concurrent with
increased carotid intima–media thickness in these patients.
Conclusion Laser speckle contrast imaging identifies
endothelial-dependent and endothelial-independent
microvascular dysfunction in individuals presenting with
EOCAD, and thus could be valuable as an early peripheral
marker of atherothrombotic disease.
Palabras clave en ingles
Carotid intima–media thicknessMicrovascular smooth muscle dysfunction
Microvascular reactivity
Microvascular endothelial dysfunction
Laser speckle
Early-onset coronary artery disease
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