Author | Bittencourt, Achilea Candida Lisboa | |
Author | Mota, Karla Oliveira | |
Author | Oliveira, Rodrigo Ferreira de | |
Author | Vallve, Maria de Lourdes Farre | |
Access date | 2015-06-08T12:41:07Z | |
Available date | 2015-06-08T12:41:07Z | |
Document date | 2009 | |
Citation | BITTENCOURT, A. C. L. et al. A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. American Journal of Dermatopathology, v. 31, n. 8, p. 834-837, 2009. | pt_BR |
ISSN | 1533-0311 | |
URI | https://www.arca.fiocruz.br/handle/icict/10649 | |
Language | eng | pt_BR |
Publisher | Lippincott Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Title | A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with clinicopathological aspects of mycosis fungoides. A case report. | pt_BR |
Type | Article | pt_BR |
Abstract | Adult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma associated with the human T-cell lymphotropic virus (HTLV-I). We describe an adult male patient clinically and pathologically diagnosed as mycosis fungoides and treated with chemotherapy after which complete involution of the lesions occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the palmoplantar regions, followed by disseminated vesiculopapules and associated lymphocytosis. A serological test performed at this time revealed HTLV-I infection, and a diagnosis of chronic ATL was made. Monoclonal integration of HTLV-I was detected in peripheral blood mononuclear cells by inverse long polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, and intraepidermal vesicles with atypical lymphocytes and an infiltration of small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with confirmation of HTLV-I proviral integration. The delay that occurred in diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the same clinical, histopathological, and immunohistochemical features. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia, Medicina Interna. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
Subject | Adult T-cell leukemia/lymphoma, | pt_BR |
Subject | Mycosis fungoides | pt_BR |
Subject | HTLV-I infection | pt_BR |
DeCS | Eczema Disidrótico/patologia | pt_BR |
DeCS | Infecções por HTLV-I/patologia | pt_BR |
DeCS | Leucemia-Linfoma de Células T do Adulto/patologia | pt_BR |
DeCS | Micose Fungoide/patologia | pt_BR |
DeCS | Neoplasias Cutâneas/patologia | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico | pt_BR |
DeCS | Ciclofosfamida | pt_BR |
DeCS | Diabetes Mellitus | pt_BR |
DeCS | Diagnóstico Diferencial | pt_BR |
DeCS | Doxorrubicina | pt_BR |
DeCS | Eczema Disidrótico/virologia | pt_BR |
DeCS | Infecções por HTLV-I/complicações | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Leucemia-Linfoma de Células T do Adulto/quimioterapia | pt_BR |
DeCS | Micose Fungoide/quimioterapia | pt_BR |
DeCS | Neoplasias Cutâneas/quimioterapia | pt_BR |