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Autor | Gurgel, Clarissa Araújo Silva | |
Autor | Ramos, Eduardo Antônio Gonçalves | |
Autor | Azevedo, Roberto Almeida de | |
Autor | Sarmento, Viviane Almeida | |
Autor | Carvalho, Ana Maria da Silva | |
Autor | Santos, Jean Nunes dos | |
Fecha de acceso | 2015-06-16T18:42:38Z | |
Fecha de disponibilización | 2015-06-16T18:42:38Z | |
Fecha de publicación | 2008 | |
Referencia | GURGEL, C. A. S. et al. Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study. Journal of Molecular Histology, v. 39, n. 3, p. 311-316, 2008. | pt_BR |
ISSN | 1567-2379 | |
URI | https://www.arca.fiocruz.br/handle/icict/10855 | |
Idioma | eng | pt_BR |
Editor | Springer Verlag | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study. | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1007/s10735-008-9167-0 | |
Resumen en Inglés | Abstract Aim To investigate the immunohistochemical expression of Ki-67, p53 and p63 in Keratocyst Odontogenic Tumours (KOTs) in order to contribute to the biological profile of this tumor. Methods Immunohistochemical technique was performed using the EnVisionTM System in 37 cases of KOTs. Results Ki-67- and p53- immunostained cells were mainly located in the suprabasal layers. p63-positive cells were found throughout the lining cystic epithelium. No difference in the immunostaining for these proteins was observed between primary and recurrent KOTs (Ki-67: P = 0.5591; p53: P = 0.9847; p63: P = 0.9127), or between KOTs associated with Nevoid Basal Cell Carcinoma Syndrome (NBCCS) and sporadic KOTs (Ki-67: P = 0.7013; p53: P = 0.3197; p63: P = 0.2427). Conclusions It is possible that biological behavior of KOTs may be related to suprabasal proliferative compartment in the cystic epithelium as observed by high levels of Ki-67, p53 and p63. In addition, p63 immunostaining may represent immaturity of keratinocytes in KOTs, and suggests that this protein may participate in the regulation of epithelial cell differentiation. Taken together, these data may favor tumorigenesis on KOTs. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil | pt_BR |
Afiliación | Federal University of Bahia. School of Dentistry. Division of Oral Radiology. Salvador, BA, Brasil | pt_BR |
Afiliación | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Histopatologia. Salvador, BA, Brasil | pt_BR |
Afiliación | Universidade Federal da Bahia. Faculdade de Odontologia. Salvador, BA, Brasil | pt_BR |
Palavras clave en Inglês | Odontogenic cysts | pt_BR |
Palavras clave en Inglês | Keratocyst odontogenic tumour | pt_BR |
Palavras clave en Inglês | Cell proliferation | pt_BR |
Palavras clave en Inglês | Ki-67 | pt_BR |
Palavras clave en Inglês | p53 | pt_BR |
Palavras clave en Inglês | p63 | pt_BR |
DeCS | Antígeno Ki-67/metabolismo | pt_BR |
DeCS | Cistos Odontogênicos/metabolismo | pt_BR |
DeCS | Tumores Odontogênicos/metabolismo | pt_BR |
DeCS | Transativadores/metabolismo | pt_BR |
DeCS | Proteína Supressora de Tumor p53/metabolismo | pt_BR |
DeCS | Anticorpos | pt_BR |
DeCS | Contagem de Células | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imuno-Histoquímica | pt_BR |
DeCS | Cistos Odontogênicos/patologia | pt_BR |
DeCS | Tumores Odontogênicos/patologia | pt_BR |
DeCS | Fatores de Transcrição | pt_BR |