Author | Valle, Camila Zaverucha do | |
Author | Monteiro, Sérgio Pereira | |
Author | El-Jaick, Kênia Balbi | |
Author | Rosadas, Leonardo Azevedo da Silva | |
Author | Costa, Marli Jane Martins | |
Author | Quintana, Marcel de Souza Borges | |
Author | Castro, Liane de | |
Access date | 2015-06-17T17:27:19Z | |
Available date | 2015-06-17T17:27:19Z | |
Document date | 2014 | |
Citation | VALLE, Camila Zaverucha do et al. The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in brazilian patients. Tuberculosis, v.94, n.3, p.299–305, 2014. | pt_BR |
ISSN | 1472-9792 | |
URI | https://www.arca.fiocruz.br/handle/icict/10902 | |
Sponsorship | Programa Estratégico de Apoio à Pesquisa em Saúde, Fundação Oswaldo Cruz, FAPERJ | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | |
Title | The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in brazilian patients | pt_BR |
Type | Article | |
DOI | 10.1016/j.tube.2014.03.006 | |
Abstract | Tuberculosis (TB) is still a major health concern and side-effects related to the treatment, especially druginduced
hepatotoxicity (DIH), should be better investigated. In the present study, a possible association
between anti-TB DIH and cigarette smoking, N-acetyltransferase 2 (NAT2), Cytochrome P450 2E1 (CYP2E1)
and Cytochrome P450 3A4 (CYP3A4) genotypes was studied in 131 TB Brazilian patients. The NAT2 and
CYP3A4 genetic polymorphisms were determined using a polymerase chain reaction (PCR) direct
sequencing approach and genetic polymorphisms of CYP2E1 gene were determined by restriction fragment
length polymorphism (RFLP). The risk of anti-TB DIH was lower in rapid/intermediate acetylators when
compared to slowacetylators (OR: 0.34, CI 95: 0.16e0.71; p < 0.01). A decreased risk of developing anti-TB
DIH was also observed in active smokers when compared to non-smokers (OR: 0.28, 95 CI: 0.11e0.64;
p < 0.01). Significant association between CYP3A4 genotypes and hepatotoxicity was not observed, as well
as between CYP2E1 genotype and hepatotoxicity, whose frequency of patients with wild homozygous was
more prevalent. The anti-TB drugs interactions with smoking on hepatotoxicity, as well as the NAT2
phenotype, may require to adjust therapeutic regimen dosages or alarm in case of adverse event
developments. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Farmacogenética. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Farmacogenética. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Genética e Biologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Farmacogenética. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Vice-Presidência de Pesquisa. Laboratório de Referência. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Farmacogenética. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | Anti-tuberculosis drug | pt_BR |
Subject | Hepatotoxicity | pt_BR |
Subject | Liver enzymes | pt_BR |
Subject | Cigarette smoking | pt_BR |
DeCS | Tuberculose | pt_BR |
DeCS | Reação em Cadeia da Polimerase | pt_BR |
DeCS | Polimorfismo de Fragmento de Restrição | pt_BR |
DeCS | Brasil | pt_BR |
e-ISSN | 1873-281X | |