Author | Lobato, Lívia Silva | |
Author | Rosa, Patrícia Sammarco | |
Author | Ferreira, Jessica da Silva | |
Author | Neumann, Arthur da Silva | |
Author | Silva, Marlei Gomes da | |
Author | Nascimento, Dejair Caitano do | |
Author | Soares, Cleverson Teixeira | |
Author | Pedrini, Silvia Cristina Barbosa | |
Author | Oliveira, Diego Sá Leal de | |
Author | Monteiro, Cláudia Peres | |
Author | Pereira, Geraldo Moura Batista | |
Author | Alves, Marcelo Ribeiro | |
Author | Hacker, Mariana Andrea | |
Author | Moraes, Milton Ozório | |
Author | Pessolani, Maria Cristina Vidal | |
Author | Duarte, Rafael Silva | |
Author | Lara, Flávio Alves | |
Access date | 2015-06-26T13:04:35Z | |
Available date | 2015-06-26T13:04:35Z | |
Document date | 2014 | pt_BR |
Citation | LOBATO, Lívia Silva et al. Statins Increase Rifampin Mycobactericidal Effect. Antimicrobial Agents and Chemotherapy, v.58, n.10, p.5766-5774, oct. 2014. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/10976 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Statins Increase Rifampin Mycobactericidal Effect | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/AAC.01826-13 | pt_BR |
Abstract | Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been followed with great concern during
the last years, while the need for new drugs able to control leprosy and tuberculosis, mainly due to extensively drug-resistant
tuberculosis (XDR-TB), is pressing. Our group recently showed that M. leprae is able to induce lipid body biogenesis and cholesterol
accumulation in macrophages and Schwann cells, facilitating its viability and replication. Considering these previous results,
we investigated the efficacies of two statins on the intracellular viability of mycobacteria within the macrophage, as well as
the effect of atorvastatin on M. leprae infections in BALB/c mice. We observed that intracellular mycobacteria viability decreased
markedly after incubation with both statins, but atorvastatin showed the best inhibitory effect when combined with rifampin.
Using Shepard’s model, we observed with atorvastatin an efficacy in controlling M. leprae and inflammatory infiltrate in
the BALB/c footpad, in a serum cholesterol level-dependent way. We conclude that statins contribute to macrophage-bactericidal
activity against Mycobacterium bovis, M. leprae, and M. tuberculosis. It is likely that the association of statins with the actual
multidrug therapy effectively reduces mycobacterial viability and tissue lesion in leprosy and tuberculosis patients, although
epidemiological studies are still needed for confirmation. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Microbactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Instituto Lauro de Souza Lima. Departamento de Biologia. Bauru, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chgas. Centro de Pesquisa Clínica em HIV/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | niversidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Laboratório de Microbactérias. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
Subject | Mycobacterium tuberculosis | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Statins | pt_BR |
Subject | Intracellular mycobacterial | pt_BR |
Subject | Rifampin | pt_BR |
DeCS | Rifampina | pt_BR |
DeCS | Inibidores de Hidroximetilglutaril-CoA Redutases | pt_BR |
DeCS | Tuberculose | pt_BR |
DeCS | Mycobacterium leprae | pt_BR |
DeCS | Mycobacterium tuberculosis | pt_BR |
DeCS | Hanseníase | pt_BR |