Mostrar el registro sencillo del ítem
Autor | Diniz, Breno Satler | |
Autor | Reynolds III, Charles F. | |
Autor | Butters, Meryl A. | |
Autor | Dew, Mary Amanda | |
Autor | Firmo, Josélia Oliveira Araújo | |
Autor | Costa, Maria Fernanda Lima | |
Autor | Costa, Erico Castro | |
Fecha de acceso | 2015-07-07T13:06:56Z | |
Fecha de disponibilización | 2015-07-07T13:06:56Z | |
Fecha de publicación | 2014 | |
Referencia | DINIZ, Breno S. et al. The effect of gender, age, and symptom severity in late-life depression on the risk of all-cause mortality: the Bambu´i cohort study of aging. Depression and Anxiety, Vol.31, n. 9, p. 787–795, 2014 | pt_BR |
ISSN | 1520-6394 | |
URI | https://www.arca.fiocruz.br/handle/icict/11106 | |
Idioma | eng | pt_BR |
Editor | Wiley Online Library | pt_BR |
Derechos de autor | restricted access | pt_BR |
Título | The effect of gender, age, and symptom severity in late-life depression on the risk of all-cause mortality: the Bambu´i cohort study of aging | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1002/da.22226 | |
Resumen en Inglés | Background: Increased mortality risk and its moderators is an important, but still under recognized, negative outcome of late-life depression (LLD). Therefore, we aimed to evaluate whether LLD is a risk factor for all-cause mortality in a population-based study with over 10 years of follow-up, and addressed the moderating effect of gender and symptom severity on mortality risk. Methods: This analysis used data from the Bambuí Cohort Study of Aging. The study population comprised 1.508 (86.5%) of all eligible 1.742 elderly residents. Depressive symptoms were annually evaluated by the GHQ-12, with scores of five or higher indicating clinically significant depression. From 1997 to 2007, 441 participants died during 10,648 person-years of follow-up. We estimated the hazard ratio for mortality risk by Cox regression analyses. Results: Depressive symptoms were a risk factor for all-cause mortality after adjusting for confounding lifestyle and clinical factors (adjusted HR = 1.24 CI95% [1.00–1.55], P = .05). Mortality risk was significantly elevated in men (adjusted HR = 1.45 CI95% [1.01–2.07], P = 0.04), but not in women (adjusted HR = 1.13 CI95% [0.84–1.48], P = 0.15). We observed a significant interaction between gender and depressive symptoms on mortality risk ((HR = 1.72 CI95% [1.18–2.49], P = 0.004). Conclusion: The present study provides evidence that LLD is a risk factor for all-cause mortality in the elderly, especially in men. The prevention and adequate treatment of LLD may help to reduce premature disability and death among elders with depressive symptoms. | pt_BR |
Afiliación | Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saude Mental. Belo Horizonte, MG, Brazil | pt_BR |
Afiliación | University of Pittsburgh. Medical School. Department of Psychiatry. Pittsburgh, PA, USA | pt_BR |
Afiliación | University of Pittsburgh. Medical School. Department of Psychiatry. Pittsburgh, PA, USA | pt_BR |
Afiliación | University of Pittsburgh. Medical School. Department of Psychiatry. Pittsburgh, PA, USA | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Social e Preventiva. Belo Horizonte, MG, Brazil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Social e Preventiva. Belo Horizonte, MG, Brazil | pt_BR |
Palavras clave en Inglês | ate-life depression | pt_BR |
Palavras clave en Inglês | mortality | pt_BR |
Palavras clave en Inglês | cohort study | pt_BR |
Palavras clave en Inglês | risk factor | pt_BR |