Autor | Alcântara, Keila Correia | |
Autor | Reis, Monica Nogueira Guarda | |
Autor | Cardoso, Ludimila Paula Vaz | |
Autor | Bello, Gonzalo | |
Autor | Stefani, Mariane Martins Araújo | |
Data de acesso | 2015-07-13T12:46:47Z | |
Data de disponibilização | 2015-07-13T12:46:47Z | |
Data do publicação | 2013 | pt_BR |
Citação | ALCÂNTARA, Keila Correia; et al. Increasing Heterosexual Transmission of HIV-1 Subtype C in Inland Central Western Brazil. J Med Virol. v.85, n.3, p.396-404, Mar. 2013. | pt_BR |
ISSN | 1096-9071 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/11220 | |
Idioma | eng | pt_BR |
Editor | Wiley Periodicals Inc. | pt_BR |
Direito Autoral | restricted access | pt_BR |
Título | Increasing Heterosexual Transmission of HIV-1 Subtype C in Inland Central Western Brazil | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | 10.1002/jmv.23474 | pt_BR |
Resumo em Inglês | The molecular epidemiology of HIV-1 in Brazil is
complex and heterogeneous because several
subtypes co-circulate with some important regional
differences. This study evaluated HIV-1
subtypes amongst pregnant women living in the
metropolitan area and in the interior cities from
central western Brazil. From June 2008 to June
2010, 86.9% of confirmed cases of HIV-1 infection
amongst pregnant women (172 out of 198 cases)
were recruited in Goiania/Goias state. The HIV-1
pol gene was sequenced after nested-PCR. HIV-1
subtypes were assigned by REGA, phylogenetic,
and bootscan analyses. The median age of participants
was 26 years (15–41 years range); 58.7%
of participants were diagnosed during prenatal
care and 51.7% of participants came from >50
interior cities within Goias state. Amongst the
131 HIV-1 pol sequences, 64.9% were subtype B,
13.0% were BF1 recombinant, 11.4% were
subtype C, 7.6% were subtype F1, and 2.3% were
BC recombinant. According to the HIV-1 diagnosis
date (1994–2010), a significant increase
in subtype C and a decrease of BF1 mosaics
were observed over time. All subtype C patients
lived in interior cities where the highest prevalence
of subtype C outside southern Brazil
was observed (18.4%). Phylogenetic analysis
revealed multiple independent introductions of
the Brazilian subtype C clade from the southern/
southeastern regions of Brazil. The HIV-1 epidemic
in women from central western Brazil
infected by the heterosexual route is characterized
by an unexpectedly high prevalence of subtype
C viruses highly related to those circulating
in southern/southeastern Brazil. These findings
highlight the importance of molecular surveillance
programs outside large metropolitan
regions in Brazil. | pt_BR |
Afiliação | Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil. | pt_BR |
Afiliação | Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil. | pt_BR |
Afiliação | Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliação | Universidade Federal de Goiás. Instituto de Saúde Pública e Patologia Tropical. Goiânia, GO, Brasil. | pt_BR |
Palavras-chave em inglês | HIV-1 subtype C | pt_BR |
Palavras-chave em inglês | Heterosexual transmission | pt_BR |
Palavras-chave em inglês | Pregnant women | pt_BR |
Palavras-chave em inglês | Brazil | pt_BR |
DeCS | Gestantes | pt_BR |
DeCS | HIV-1 | pt_BR |
DeCS | Brasil | pt_BR |