Author | Moraes, Vanessa Silva | |
Author | Ferreira, Jaqueline Maria Siqueira | |
Author | Coelho, Paulo Marcos Zech | |
Author | Grenfell, Rafaella Fortini Queiroz | |
Access date | 2015-07-17T17:59:59Z | |
Available date | 2015-07-17T17:59:59Z | |
Document date | 2014 | |
Citation | MORAES, Vanessa Silva et al. Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis. Acta Trop., vol. 132, p. 75-79, 2014. | pt_BR |
ISSN | 0001-706X | |
URI | https://www.arca.fiocruz.br/handle/icict/11394 | |
Language | eng | pt_BR |
Publisher | Elsevier Ltd. | pt_BR |
Rights | restricted access | pt_BR |
Title | Biomarkers for schistosomiasis: Towards an integrative view of the search for an effective diagnosis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.actatropica.2013.12.024 | |
Abstract | Human schistosomiasis, caused mainly by Schistosoma mansoni, S. japonicum, and S. hematobium, remains a prevalent and serious parasitic disease worldwide. Although it is a debilitating disease, a lack of sensitive methods for the precise diagnosis of active infection cases is important to prevent morbidity. The optimization of new diagnostic approaches may be accomplished by the selection of specific markers. In that manner, markers can be satisfactorily used for detection of different phases of infection, as acute and chronic phases, pre-patent and post-patent phases and after chemotherapy, improving the efficiency of methods. For that purpose, proteomics and glycomics analyses have been performed in schistosomes, in particular S. mansoni, using powerful high-throughput methodologies. These investigations have not only chartered protein, o-glycan and n-glycan profiles across developmental stages within mammalian host, but are also leading to the characterization of features of the surface tegument, the eggshell and excretory-secretory proteomes of schistosomes. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte, MG, Brazil/Universidade Federal de São João Del-Rei. Laboratorio de Microbiologia. Divinópolis, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de São João Del-Rei. Laboratorio de Microbiologia. Divinópolis, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Esquistossomose. Belo Horizonte, MG, Brazil | pt_BR |
Subject | Adult worm | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Diagnosis | pt_BR |
Subject | Egg | pt_BR |
Subject | Schistosomiasis mansoni | pt_BR |
Subject | Schistossomula | pt_BR |