Author | Gazzinelli, Ricardo Tostes | |
Author | Mendonca Neto, Rondon | |
Author | Lilue, Jingtao | |
Author | Howard, Jonathan | |
Author | Sher, Alan | |
Access date | 2015-07-21T17:59:20Z | |
Available date | 2015-07-21T17:59:20Z | |
Document date | 2014 | |
Citation | GAZZINELLI, Ricardo Tostes et al. Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men. Cell Host Microbe, vol. 15, n. 2, p. 132-8. 2014 | pt_BR |
ISSN | 1931-3128 | |
URI | https://www.arca.fiocruz.br/handle/icict/11397 | |
Language | eng | pt_BR |
Publisher | Cell Press | pt_BR |
Rights | open access | pt_BR |
Title | Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.chom.2014.01.004 | |
Abstract | Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Division of Infectious Diseases and Immunology. Worcester, MA, USA | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Bioquimica e Imunologia. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | University of Cologne. Institute for Genetics. Cologne, Germany | pt_BR |
Affilliation | University of Cologne. Institute for Genetics. Cologne, Germany/Instituto Gulbenkian de Ciencia. Oeiras, Portugal | pt_BR |
Affilliation | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA | pt_BR |
Subject | Toxoplasma gondii | pt_BR |