Author | Delatorre, Edson | |
Author | Bello, Gonzalo | |
Access date | 2015-08-19T13:49:17Z | |
Available date | 2015-08-19T13:49:17Z | |
Document date | 2013 | pt_BR |
Citation | DELATORRE, Edson; BELLO, Gonzalo. Phylodynamics of the HIV-1 Epidemic in Cuba. Plos One, v.8, n.9, 12p, 2013. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/11475 | |
Language | eng | pt_BR |
Publisher | Plos One | pt_BR |
Rights | open access | pt_BR |
Title | Phylodynamics of the HIV-1 Epidemic in Cuba | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0072448 | pt_BR |
Abstract | Previous studies have shown that the HIV-1 epidemic in Cuba displayed a complex molecular epidemiologic profile with
circulation of several subtypes and circulating recombinant forms (CRF); but the evolutionary and population history of
those viral variants remains unknown. HIV-1 pol sequences of the most prevalent Cuban lineages (subtypes B, C and G,
CRF18_cpx, CRF19_cpx, and CRFs20/23/24_BG) isolated between 1999 and 2011 were analyzed. Maximum-likelihood
analyses revealed multiple introductions of subtype B (n$66), subtype C (n$10), subtype G (n$8) and CRF18_cpx (n$2)
viruses in Cuba. The bulk of HIV-1 infections in this country, however, was caused by dissemination of a few founder strains
probably introduced from North America/Europe (clades BCU-I and BCU-II), east Africa (clade CCU-I) and central Africa (clades
GCU, CRF18CU and CRF19CU), or locally generated (clades CRFs20/23/24_BG). Bayesian-coalescent analyses show that the
major HIV-1 founder strains were introduced into Cuba during 1985–1995; whereas the CRFs_BG strains emerged in the
second half of the 1990s. Most HIV-1 Cuban clades appear to have experienced an initial period of fast exponential spread
during the 1990s and early 2000s, followed by a more recent decline in growth rate. The median initial growth rate of HIV-1
Cuban clades ranged from 0.4 year21 to 1.6 year21. Thus, the HIV-1 epidemic in Cuba has been a result of the successful
introduction of a few viral strains that began to circulate at a rather late time of the AIDS pandemic, but then were rapidly
disseminated through local transmission networks. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Cuba | pt_BR |
Subject | HIV-1 Epidemic | pt_BR |