Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/11685
Tipo
ArtículoDerechos de autor
Acceso abierto
Colecciones
- IOC - Artigos de Periódicos [12500]
Metadatos
Mostrar el registro completo del ítem
IDENTIFICATION OF NOVEL RECOMBINANTS OF HEPATITIS B VIRUS GENOTYPES F AND G IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS FROM ARGENTINA AND BRAZIL
Genotypes F and G
Human Immunodeficiency
Argentina
Brazil
Virus-positive patients
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Hepato-Gastroenterologia. Salvador, BA, Brasil.
University of Rosario. School of Medicine. Department of Gastroenterology and Hepatology. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Hepato-Gastroenterologia. Salvador, BA, Brasil.
University of Rosario. School of Medicine. Department of Gastroenterology and Hepatology. Rosario, Argentina.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France.
Resumen en ingles
Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a coinfecting
HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two
human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of
HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the
American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent
in both patients, with .99% of colonies hybridizing to a probe specific for this insertion.
Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and
F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively.
Bootscanning analysis provided evidence of recombination in several clones from both patients,
with recombination breakpoints located mainly at the precore/core region. These data should
encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV
co-infected patients.
Palabras clave en ingles
Hepatitis BGenotypes F and G
Human Immunodeficiency
Argentina
Brazil
Virus-positive patients
Compartir