Author | Silva, Giselle Aparecida Fagundes | |
Author | Romero, Gustavo Adolfo Sierra | |
Author | Cupolillo, Elisa | |
Author | Yamashita, Ellen Priscila Gadelha | |
Author | Silva, Adriano Gomes | |
Author | Guerra, Jorge Augusto de Oliveira | |
Author | Cruz, Alda Maria da | |
Access date | 2015-11-12T13:07:03Z | |
Available date | 2015-11-12T13:07:03Z | |
Document date | 2015 | |
Citation | SILVA, Giselle Aparecida Fagundes; et al. Leishmania (Viannia) naiffi: rare enough to be neglected?. Mem Inst Oswaldo Cruz, v.110, n.6, p.797-800, Sept. 2015. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/12204 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | |
Subject in Portuguese | Amazônia | pt_BR |
Title | Leishmania (Viannia) naiffi: rare enough to be neglected? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760150128 | |
Abstract | In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum
of clinical manifestations due, in part, to the circulation of at least seven Leishmania species. Few reports of Leishmania
(Viannia) naiffi infection suggest that its occurrence is uncommon and the reported cases present a benign
clinical course and a good response to treatment. This study aimed to strengthen the clinical and epidemiological
importance of L. (V.) naiffi in the Amazon Region (Manaus, state of Amazonas) and to report therapeutic failure in
patients infected with this species. Thirty Leishmania spp samples isolated from cutaneous lesions were characterised
by multilocus enzyme electrophoresis. As expected, the most common species was Leishmania (V.) guyanensis
(20 cases). However, a relevant number of L. (V.) naiffi patients (8 cases) was observed, thus demonstrating that
this species is not uncommon in the region. No patient infected with L. (V.) naiffi evolved to spontaneous cure until
the start of treatment, which indicated that this species may not have a self-limiting nature. In addition, two of the
patients experienced a poor response to antimonial or pentamidine therapy. Thus, either ATL cases due to L. (V.)
naiffi cannot be as uncommon as previously thought or this species is currently expanding in this region. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Gerência de Leishmaniose. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Laboratório Multiusuário. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Gerência de Leishmaniose. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas, Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leishmania (Viannia) naiffi | pt_BR |
Subject | Therapeutic failure | pt_BR |
Subject | Clinical outcome | pt_BR |
Subject | Multilocus enzyme electrophoresis | pt_BR |
Subject | Amazon Region | pt_BR |
Subject | American tegumentary leishmaniasis (ATL) | pt_BR |
DeCS | Leishmania | pt_BR |
e-ISSN | 1678-8060 | |