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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12488]
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PREFERENTIAL ASSOCIATED ANOMALIES IN 818 CASES OF MICROTIA IN SOUTH AMERICA
Birth defects
Multiple congenital anomalies
Epidemiology
South America
Autor(es)
Afiliação
University of Washington. Department of Pediatrics. Division of Craniofacial Medicine. Washington, DC, USA / Seattle Children’s Research Institute. Center for Tissue and Cell Sciences. Seattle, Washington, USA.
University of Washington. Department of Pediatrics. Division of Craniofacial Medicine. Washington, DC, USA / Seattle Children’s Research Institute. Center for Tissue and Cell Sciences. Seattle, Washington, USA / Monash University. Department of Anatomy & Developmental Biology. Clayton, Victoria, Australia.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil.
University of Washington. Department of Pediatrics. Division of Craniofacial Medicine. Washington, DC, USA / Seattle Children’s Research Institute. Center for Tissue and Cell Sciences. Seattle, Washington, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil / INAGEMP (Instituto Nacional de Genética Médica Populacional), Rio de Janeiro, RJ, Brasil.
University of Washington. Department of Pediatrics. Division of Craniofacial Medicine. Washington, DC, USA / Seattle Children’s Research Institute. Center for Tissue and Cell Sciences. Seattle, Washington, USA / Monash University. Department of Anatomy & Developmental Biology. Clayton, Victoria, Australia.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil.
University of Washington. Department of Pediatrics. Division of Craniofacial Medicine. Washington, DC, USA / Seattle Children’s Research Institute. Center for Tissue and Cell Sciences. Seattle, Washington, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia de Malformações Congênitas. ECLAMC. Rio de Janeiro, RJ, Brasil / INAGEMP (Instituto Nacional de Genética Médica Populacional), Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
The etiology of microtia remains unknown in most cases. The identification of patterns of
associated anomalies (i.e., other anomalies that occur with a given congenital anomaly in a higher
than expected frequency), is a methodology that has been used for research into the etiology of
birth defects. We conducted a study based on cases of microtia that were diagnosed from more
than 5 million live (LB)- and stillbirths (SB) examined in hospitals participating in ECLAMC
(Latin American Collaborative Study of Congenital Malformations) between 1967 and 2009. We
identified 818 LB and SB with microtia and at least one additional non-related major congenital
anomaly (cases) and 15,969 LB and SB with two or more unrelated major congenital anomalies
except microtia (controls). A logistic regression analysis was performed to identify the congenital
anomalies preferentially associated with microtia. Preferential associations were observed for 10
congenital anomalies, most of them in the craniofacial region, including facial asymmetry, choanal
atresia, and eyelid colobomata. The analysis by type of microtia showed that for anomalies such as
cleft lip and palate, macrostomia, and limb reduction defects, the frequency increased with the
severity of the microtia. In contrast, for other anomalies the frequency tended to be the same
across all types of microtia. Based on these results we will integrate data on the developmental
pathways related to preferentially associated congenital anomalies for future studies investigating
the etiology of microtia.
Palavras-chave
América do SulPalavras-chave em inglês
MicrotiaBirth defects
Multiple congenital anomalies
Epidemiology
South America
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