Author | Fonseca, Cristina Toscano | |
Author | Oliveira, Sergio Costa | |
Author | Alves, Clarice Carvalho | |
Access date | 2016-01-19T17:23:17Z | |
Available date | 2016-01-19T17:23:17Z | |
Document date | 2015 | |
Citation | FONSECA, Cristina Toscano; OLIVEIRA, Sergio Costa; ALVES, Clarice Carvalho. Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?. Front Immunol. , vol. 6, p. 95, 2015 | pt_BR |
ISSN | 1664-3224 | |
URI | https://www.arca.fiocruz.br/handle/icict/12560 | |
Language | eng | pt_BR |
Publisher | Frontiers Research Foundation | pt_BR |
Rights | open access | pt_BR |
Title | Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fimmu.2015.00095. | |
Abstract | The successful development of vaccines depends on the knowledge of the immunological mechanisms associated with the elimination of the pathogen. In the case of schistosomes, its complex life cycle and the mechanisms developed to evade host immune system, turns the development of a vaccine against the disease into a very difficult task. Identifying the immunological effector mechanisms involved in parasite attrition and the major targets for its response is a key step to formulate an effective vaccine. Recent studies have described some promising antigens to compose a subunit vaccine and have pointed to some immune factors that play a role in parasite elimination. Here, we review the immune components and effector mechanisms associated with the protective immunity induced by those vaccine candidates and the lessons we have learned from the studies of the acquired resistance to infection in humans. We will also discuss the immune factors that correlate with prot | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil/Ministério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Ministério de Ciência Tecnologia e Inovação. Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brasil | pt_BR |
Subject | schistosome vaccine | pt_BR |
Subject | protective immunity | pt_BR |
Subject | schistosomiasis | pt_BR |
Subject | effector mechanisms | pt_BR |
Subject | immune response | pt_BR |
xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |