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Autor | Kaiser, Sérgio E. | |
Autor | Sanjuliani, Antonio F. | |
Autor | Estato, Vanessa | |
Autor | Gomes, Marilia B. | |
Autor | Tibiriçá, Eduardo | |
Fecha de acceso | 2016-01-28T14:44:26Z | |
Fecha de disponibilización | 2016-01-28T14:44:26Z | |
Fecha de publicación | 2013 | |
Referencia | KAISER, Sérgio E. et al. Antihypertensive Treatment Improves Microvascular Rarefaction and Reactivity in Low-Risk Hypertensive Individuals. Microcirculation, v.20, n.8, p.703-716, 2013. | pt_BR |
ISSN | 1073-9688 | |
URI | https://www.arca.fiocruz.br/handle/icict/12648 | |
Idioma | eng | pt_BR |
Editor | Wiley | pt_BR |
Derechos de autor | restricted access | |
Palabras clave en Portugués | Vídeo capilaroscopia | pt_BR |
Palabras clave en Portugués | Disfunção microvascular | pt_BR |
Palabras clave en Portugués | Rarefação capilar | pt_BR |
Palabras clave en Portugués | Hipertensão | pt_BR |
Título | Antihypertensive Treatment Improves Microvascular Rarefaction and Reactivity in Low-Risk Hypertensive Individuals | pt_BR |
Tipo del documento | Article | |
DOI | 10.1111/micc.12067 | |
Resumen en Inglés | To test whether long-term antihypertensive treatment with metoprolol succinate (a β₁-adrenoceptor blocker) or olmesartan medoxomil (an angiotensin II AT₁-receptor blocker) reverses microvascular dysfunction in hypertensive patients. METHODS: This study included 44 hypertensive outpatients and 20 age and sex-matched healthy controls. We used skin capillaroscopy to measure capillary density and recruitment at rest and during PORH. Endothelium-dependent vasodilation of skin microcirculation was evaluated with a LDPM system in combination with ACh iontophoresis, PORH, and LTH. RESULTS: Pretreatment capillary density in hypertensive patients was significantly reduced compared with controls (71.3 ± 1.5 vs. 80.6 ± 1.8 cap/mm²; p < 0.001), as was PORH (71.7 ± 1.5 vs. 79.5 ± 2.6 cap/mm²; p < 0.05). After treatment for six months, capillary density increased to 75.4 ± 1.1 cap/mm² (p < 0.01) at rest and 76.8 ± 1.1 cap/mm² during PORH. During LTH, CVC in perfusion units (PU)/mmHg was similar in patients (1.71 [1.31-2.12]) and controls (1.60 [1.12-1.91]) and increased significantly (1.82 [1.30-2.20]) after treatment. Maximal CVC during PORH was reduced in hypertensive patients (0.30 [0.22-0.39]) compared to controls (0.39 [0.31-0.49], p < 0.001) and increased (0.41 [0.29-0.51], p < 0.001) after treatment. CONCLUSIONS: Capillary rarefaction and microvascular endothelial dysfunction in hypertensive patients responded favorably to long-term pharmacological treatment. | pt_BR |
Afiliación | Universidade do Estado do Rio de Janeiro. Unidade de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Universidade do Estado do Rio de Janeiro. Unidade de Fisiopatologia Clínica e Experimental. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Universidade do Estado do Rio de Janeiro. Unidade de Diabetes. Rio de Janeiro, RJ, Braisl. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Palavras clave en Inglês | Capillary rarefaction | pt_BR |
Palavras clave en Inglês | Hypertension | pt_BR |
Palavras clave en Inglês | Microvascular disfunction | pt_BR |
Palavras clave en Inglês | video capillaroscopy | pt_BR |
e-ISSN | 1549-8719 |
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IOC - Artigos de Periódicos [12500]