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Autor | Araújo, Caliandra Pinto | |
Autor | Gurgel, Clarissa Araújo Silva | |
Autor | Ramos, Eduardo Antônio Gonçalves | |
Autor | Freitas, Valéria Souza | |
Autor | Barbosa Junior, Aryon de Almeida | |
Autor | Ramalho, Luciana Maria Pedreira | |
Autor | Santos, Jean Nunes dos | |
Fecha de acceso | 2016-03-03T17:20:58Z | |
Fecha de disponibilización | 2016-03-03T17:20:58Z | |
Fecha de publicación | 2010 | |
Referencia | ARAÚJO, C. P. et al. Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis. Journal of Molecular Histology, v. 41, p. 357-365, 2010. | pt_BR |
ISSN | 1567-2379 | |
URI | https://www.arca.fiocruz.br/handle/icict/12968 | |
Idioma | eng | pt_BR |
Editor | Springer Verlag | pt_BR |
Derechos de autor | open access | pt_BR |
Título | Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1010.1007/s10735-010-9297-z07/s10735-010-9297-z | |
Resumen en Inglés | LCs and MCs are known to be directly influenced by UV radiation. This study investigated the presence of Langerhans cells (LCs) and mast cells (MCs) in actinic cheilitis (AC) exhibiting epithelial dysplasia (ED). Using immunohistochemistry for CD1a and mast cell tryptase, LCs and MCs density was assessed in 35 cases of AC with different degrees of ED. LCs were found in 32 cases of AC whereas MCs were found in all cases. There was an increase in LCs density irrespective of degree of ED when the cases were compared to normal lip mucosa (P = 0.04343). No statistical difference in LCs density was observed regarding the different degrees of dysplasia (P[0.05). Significant difference in MCs density between mild and moderate dysplasia and normal lip mucosa was found (P\0.05). No significant correlation between LCs and MCs was seen (P = 0.1258). Although no correlation could be established between LCs and MCs and the different degrees of ED; it is possible that the accumulation of LCs plays an immunostimulatory and protective role in the defense against progression of dysplasia. Further studies are necessary to determine the role of MCs in the development of AC. | pt_BR |
Afiliación | Federal University of Bahia. School of Dentistry. Department of Oral Pathology, Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | State University of Feira de Santana. Department of Health. Feira de Santana, BA, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | State University of Feira de Santana. Department of Stomatology. Feira de Santana, BA, Brasil | pt_BR |
Afiliación | Federal University of Bahia. School of Dentistry. Department of Oral Pathology, Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
Palavras clave en Inglês | Actinic chelitis | pt_BR |
Palavras clave en Inglês | Langerhans cells | pt_BR |
Palavras clave en Inglês | Mast cells | pt_BR |
Palavras clave en Inglês | Epithelial dysplasia | pt_BR |