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ZIKA VIRUS: HISTORY, EMERGENCE, BIOLOGY, AND PROSPECTS FOR CONTROL
Dengue
Epidemia
Transmissão
Mosquitos
Microcefalia
Surto de doenças
Vacinas
História
Controle
Situação de emergência
Author
Affilliation
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Microbiology & Immunology. Galveston TX, USA / University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston TX, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil
University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA / Duke-NUS Medical School. Programme in Emerging Infectious Diseases. Singapore
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil
University of Texas Medical Branch. Department of Obstetrics and Gynecology. Galveston, TX, USA
University of Texas Medical Branch. Department of Biochemistry & Molecular Biology, and Sealy Center for Structural Biology & Molecular Biophysics. Galveston, TX, USA / University of Texas Medical Branch. Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics. Galveston, TX, USA
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Microbiology & Immunology. Galveston TX, USA / University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston TX, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil
University of Texas Medical Branch. Department of Biochemistry & Molecular Biology. Galveston, TX, USA / Duke-NUS Medical School. Programme in Emerging Infectious Diseases. Singapore
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto da Saúde Coletiva. Salvador, BA, Brasil
University of Texas Medical Branch. Department of Obstetrics and Gynecology. Galveston, TX, USA
University of Texas Medical Branch. Department of Biochemistry & Molecular Biology, and Sealy Center for Structural Biology & Molecular Biophysics. Galveston, TX, USA / University of Texas Medical Branch. Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics. Galveston, TX, USA
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Microbiology & Immunology. Galveston TX, USA / University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston TX, USA
Abstract
Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis
and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in
Micronesia, the South Pacific, and most recently the Americas. After its putative evolution in sub-Saharan
Africa, ZIKV spread in the distant past to Asia and has probably emerged on multiple occasions into urban
transmission cycles involving Aedes (Stegomyia) spp. mosquitoes and human amplification hosts,
accompanied by a relatively mild dengue-like illness. The unprecedented numbers of people infected
during recent outbreaks in the South Pacific and the Americas may have resulted in enough ZIKV infections
to notice relatively rare congenital microcephaly and GuillaineBarr e syndromes. Another hypothesis
is that phenotypic changes in Asian lineage ZIKV strains led to these disease outcomes. Here, we
review potential strategies to control the ongoing outbreak through vector-centric approaches as well as
the prospects for the development of vaccines and therapeutics
Keywords in Portuguese
Zika virusDengue
Epidemia
Transmissão
Mosquitos
Microcefalia
Surto de doenças
Vacinas
História
Controle
Situação de emergência
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