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Autor | Andrade, Sonia Gumes | pt_BR |
Autor | Magalhães, Juracy Barbosa | pt_BR |
Autor | Pontes, Albélia Lima | pt_BR |
Fecha de acceso | 2016-06-27T16:25:28Z | pt_BR |
Fecha de acceso | 2016-07-07T11:39:43Z | |
Fecha de disponibilización | 2016-06-27T16:25:28Z | pt_BR |
Fecha de disponibilización | 2016-07-07T11:39:43Z | |
Fecha de publicación | 1985 | pt_BR |
Referencia | ANDRADE, S. G.; MAGALHÃES, J. B.; PONTES, A. L. Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types. Bulletin ofthe World Health Organization, v. 63, n. 4, p. 721-726, 1985. | pt_BR |
ISSN | 0042-9686 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/14622 | |
Idioma | eng | pt_BR |
Editor | World Health Organization | pt_BR |
Derechos de autor | open access | pt_BR |
Palabras clave en Portugués | Nifurtimox | pt_BR |
Palabras clave en Portugués | Benzonidazole | pt_BR |
Palabras clave en Portugués | Trypanosoma cruzi | pt_BR |
Palabras clave en Portugués | Xenodiagnóstico | pt_BR |
Palabras clave en Portugués | Doença de Chagas | pt_BR |
Palabras clave en Portugués | Animal | pt_BR |
Título | Evaluation of chemotherapy with benznidazole and nifurtimox in mice infected with Trypanosoma cruzi strains of different types | pt_BR |
Tipo del documento | Article | pt_BR |
Resumen en Inglés | A test was made of the susceptibility of 30 strains of Trypanosoma cruzi to chemotherapy with nifurtimox (Bay 2502) and benznidazole (Ro 7-1051). The strains had previously been classified as type I, II, or III according to their morphobiological and isoenzymic characteristics. Three type I strains, 14 type II strains, and 13 type III strains were studied. Mice were infected with 2 x IO6 bloodforms ofthese parasites and treatedfor 90 days with benznidazole or nifurtimox. All the surviving mice were submitted to parasitological tests (directparasitaemia, xenodiagnosis, inoculation in new-born mice, and haemoculture) andserological tests (indirect immunofluorescence). As the latter remainedpositive in about 80% of the parasitologically negative animals, the cure rates were based on the more reliable parasitological tests. Type I strains displayed high susceptibility, type II strains showed medium to high susceptibility, and type III strains were highly resistant to both drugs. Thefact that aparticular strain type, with its own level ofsusceptibility, usually predominates in a given geographical area may explain the contradictory results after chemotherapy from different endemic areas. | pt_BR |
Afiliación | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliación | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |