Author | Morgado, Mariza Gonçalves | |
Author | Sabino, Ester Cerdeira | |
Author | Shpaer, Eugene G | |
Author | Bongertz, Vera | |
Author | Brigido, Luís Fernando de Macedo | |
Author | Guimaraes, Mark Drew Crosland | |
Author | Castilho, Euclides Ayres de | |
Author | Castro Filho, Bernardo Galvão | |
Author | Mullins, James I | |
Author | Hendry, R Michael | |
Author | Mayer, Allen | |
Access date | 2016-07-21T18:52:40Z | |
Available date | 2016-07-21T18:52:40Z | |
Document date | 1994 | |
Citation | MORGADO, M. G. et al. V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F. AIDS Research and Human Retroviruses, v. 10, n. 5, p. 569-576, 1994. | pt_BR |
ISSN | 0889-2229 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15056 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert | pt_BR |
Rights | open access | pt_BR |
Title | V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/aid.1994.10.569 | |
Abstract | Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and São Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently in Brazil and in Romania (one appeared to be a B/F recombinant). Octameric sequences at the tip of the subtype B V3 loops were variable and distinct from those prevalent in North America and Europe. The GPGR motif, prevalent in North American/European strains, was found in only 8 (28.5%) sequences, whereas GWGR was found in 12 (43%) and novel sequences in 8 (28.5%). Brazilian subtype B sequences also diverged from the consensus North American/European strains over the remainder of the V3 loop. These results suggest that Brazilian HIV-1 B strains may have important antigenic differences from prototype subtype B strains currently being evaluated for use in HIV vaccines. These results should be taken into account for future vaccine programs in Brazil. | pt_BR |
Affilliation | FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil / Irwin Memorial Blood Centers. San Francisco, California | pt_BR |
Affilliation | Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, California | pt_BR |
Affilliation | FIOCRUZ. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Instituto Adolfo Lutz. São Paulo, SP, Brasil | pt_BR |
Affilliation | FIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, Brasil / Minas Gerais University. Department of Preventive Medicine. Minas Gerais, BH, Brasil | pt_BR |
Affilliation | FIOCRUZ. Instituto Oswaldo Cruz. Centro de Info para a Saude. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Stanford University. School of Medicine. Department of Microbiology and Immunology. Stanford, California | pt_BR |
Affilliation | Viral and Rickettsial Disease Laboratory. California Department of Health Services. Berkeley, California | pt_BR |
Affilliation | Irwin Memorial Blood Centers. San Francisco, California | pt_BR |
Subject | AIDS Vaccines | pt_BR |
Subject | Amino Acid Sequence | pt_BR |
Subject | DNA, Viral | pt_BR |
Subject | HIV Infections | pt_BR |
Subject | Brazil | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Humans | pt_BR |
Subject | Molecular Sequence Data | pt_BR |
Subject | Phylogeny | pt_BR |
Subject | Polymerase Chain Reaction | pt_BR |