Author | Rocha, Viviane Costa Junqueira | |
Author | França, Luciana Souza de Aragão | |
Author | Araújo, Cintia Figueiredo de | |
Author | Ng, Ayling Martins | |
Author | Andrade, Candace Machado de | |
Author | Andrade, André Cronemberger | |
Author | Santos, Emanuelle de Souza | |
Author | Silva, Mariana da Cruz Borges | |
Author | Macambira, Simone Garcia | |
Author | Noronha-Dutra, Alberto Augusto | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Access date | 2016-08-04T17:19:15Z | |
Available date | 2016-08-04T17:19:15Z | |
Document date | 2016 | |
Citation | ROCHA, V. C. J. et al. Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice. Cancer Chemotherapy and Pharmacology, v. 77, p. 659–662, 2016. | pt_BR |
ISSN | 0344-5704 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15196 | |
Language | eng | pt_BR |
Publisher | Springer Verlag | pt_BR |
Rights | open access | pt_BR |
Title | Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s00280-015-2949-7 | |
Abstract | Doxorubicin (DOX) is a chemotherapeutic that is widely used for the treatment of many human tumors. However, the development of cardiotoxicity has limited its use. The aim of the present study was to evaluate the possible efficacy of mito-TEMPO (mito-T) as a protective agent against DOX-induced cardiotoxicity in mice. Methods C57BL/6 mice were treated twice with mito-
T at low (5 mg/kg body weight) or high (20 mg/kg body
weight) dose and once with DOX (24 mg/kg body weight)
or saline (0.1 mL/20 g body weight) by means of intraperitoneal
injections. The levels of malondialdehyde (MLDA),
a marker of lipid peroxidation, and serum levels of creatine
kinase were evaluated 48 h after the injection of DOX.
Results DOX induced lipid peroxidation in heart mitochondria
(p < 0.001), and DOX-treated mice receiving
mito-T at low dose had levels of MLDA significantly
lower than the mice that received only DOX (p < 0.01).
Furthermore, administration of mito-T alone did not cause
any significant changes from control values. Additionally,
DOX-treated mice treated with mito-T at high dose showed
decrease in serum levels of total CK compared to mice
treated with DOX alone (p < 0.05). Conclusion Our results indicate that mito-T protects mice
against DOX-induced cardiotoxicity. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de São Paulo. Laboratório de Imunologia Celular e Bioquímica de Fungos e Protozoários. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / University College London. Gower Street, London, UK | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Doxorubicin | pt_BR |
Subject | Cardiotoxicity | pt_BR |
Subject | Mitochondria | pt_BR |
Subject | Mito-TEMPO | pt_BR |
Subject | Creatine kinase | pt_BR |
Subject | Lipid peroxidation | pt_BR |
Subject | Cardiotonic agents | pt_BR |
Subject | Antibiotics | pt_BR |