Author | Sousa, Lourimar Viana Nascimento Franco de | |
Author | Santos, Vera Lúcia dos | |
Author | Monteiro, Andrea de Souza | |
Author | Souza, Marcus Vinicíus Dias | |
Author | Marques, Sirlei Garcia | |
Author | Faria, Elaine Speziali de | |
Author | Assunção, Elaine Alves de Oliveira | |
Author | Santos, Simone Gonçalves dos | |
Author | Zonis, Juan Moises | |
Author | Alvarenga, Daniel Gomes de | |
Author | Holanda, Rodrigo Assunção de | |
Author | Sousa, Jaqueline Gontijo de | |
Author | Santos, Kênia Valéria dos | |
Author | Stoianoff, Maria Aparecida de Resende | |
Access date | 2016-08-18T16:05:17Z | |
Available date | 2016-08-18T16:05:17Z | |
Document date | 2016 | |
Citation | SOUSA, Lourimar Viana Nascimento Franco de et al. Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype. BMC Infect Dis., v. 16, art. 86, 2016. | pt_BR |
ISSN | 1471-2334 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15309 | |
Language | eng | pt_BR |
Publisher | Biomed Central | pt_BR |
Rights | open access | pt_BR |
Title | Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s12879-016-1431-4 | |
Abstract | Background: Because of the inherent immunosuppression of cancer patients opportunistic infections by Candida spp, occur frequently. This study aimed to identify Candida species in the oral mucosa of 59 patients with orogastric cancer (OGC) and to analyze the immunological phenotype of these patients.
Methods: The yeasts were identified by MALDI-TOF mass spectrometry (MS). For all isolates, we performed phospholipases and proteinases assays, in vitro adherence to buccal epithelial cells (BEC), minimum inhibitory concentration of antifungal drugs and determined the cytokine profile by Cytometric Bead Array flow citometry assay.
Results: C. albicans was the most prevalent species in OGC patients (51.6 %) and control group (66.7 %). Candida spp. strains isolated from OGC patients exhibited better adherence to BEC (p = 0.05) than did the control group. Phospholipases production by Candida strains from OGC patients was lower (51.6 %) than in the control group (61.9 %). Proteinases were detected in 41.9 % and 4.8 % of the yeasts from OGC patients and control group, respectively. Significant differences were found in the serum of OGC patients compared to the control group for IL-2, IL-10, TNF-α, IFN-γ and IL-17.
Conclusions: The results of this work suggest increased virulence of yeasts isolated from OGC patients and, that this may interfere with the immune phenotype. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Micologia. Belo Horizonte, MG, Brasil/Universidade Vale do Rio Doce. Laboratorio de Microbiologia. Governador Valadares, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Microbiologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade CEUMA. Laboratorio de Microbiologia. São Luis, MA, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Microbiologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal do Maranhão. Hospital Universitario. São Luis, MA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoramento. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Vale do Rio Doce. Laboratorio de Microbiologia. Governador Valadares, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Laboratorio de Microbiologia Oral e Anaerobica. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Core Experts Oncologia. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Laboratorio Alvarenga. Governador Valadares, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Micologia. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Virologia Basica e Aplicada. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Federal Universidade Federal do Espirito Santo. Departamento de Patologia. Laboratorio de Bacteriologia Geral e Clinica. Centro de Ciencias da Saude. Vitória, ES, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Microbiologia. Laboratorio de Micologia. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Candida spp | pt_BR |
Subject | Orogastric cancer | pt_BR |
Subject | Virulence | pt_BR |
Subject | Antifungal | pt_BR |
Subject | Immune phenotype | pt_BR |