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THE MAJORITY OF FRESHLY SORTED SIMIAN IMMUNODEFICIENCY VIRUS (SIV)-SPECIFIC CD8(+) T CELLS CANNOT SUPPRESS VIRAL REPLICATION IN SIV-INFECTED MACROPHAGES
simian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
Autor
Afiliación
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Oregon Health Sciences University. Oregon National Primate Research Center. Vaccine and Gene Therapy Institute. Beaverton, Oregin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
University of Miami Leonard M. Miller School of Medicine. Miami, Florida, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA / Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Oregon Health Sciences University. Oregon National Primate Research Center. Vaccine and Gene Therapy Institute. Beaverton, Oregin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
University of Miami Leonard M. Miller School of Medicine. Miami, Florida, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA / Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
Resumen en ingles
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8(+) T cell-mediated lysis and continue to produce virus over long periods of time.
Palabras clave en ingles
CD4 T cellssimian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
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