Author | Antunes, Sérgio Luiz Gomes | |
Author | Chimelli, Leila | |
Author | Jardim, Márcia Rodrigues | |
Author | Vital, Robson Teixeira | |
Author | Nery, José Augusto da Costa | |
Author | Corte-Real, Suzana | |
Author | Hacker, Mariana Andréa Vilas Boas | |
Author | Sarno, Euzenir Nunes | |
Access date | 2016-08-30T15:54:39Z | |
Available date | 2016-08-30T15:54:39Z | |
Document date | 2012 | |
Citation | ANTUNES, Sérgio Luiz Gomes; et al. Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency. Mem Inst Oswaldo Cruz, v.107, n.2, p. 246-253, Mar. 2012. | pt_BR |
ISSN | 1678-8060 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15540 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Diagnóstico | pt_BR |
Subject in Portuguese | Forma neural pura | pt_BR |
Title | Histopathological examination of nerve samples from pure neural leprosy patients: obtaining maximum information to improve diagnostic efficiency | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762012000200015 | |
Abstract | Nerve biopsy examination is an important auxiliary procedure for diagnosing pure neural leprosy (PNL). When
acid-fast bacilli (AFB) are not detected in the nerve sample, the value of other nonspecific histological alterations
should be considered along with pertinent clinical, electroneuromyographical and laboratory data (the detection
of Mycobacterium leprae DNA with polymerase chain reaction and the detection of serum anti-phenolic glycolipid
1 antibodies) to support a possible or probable PNL diagnosis. Three hundred forty nerve samples [144 from PNL
patients and 196 from patients with non-leprosy peripheral neuropathies (NLN)] were examined. Both AFB-negative
and AFB-positive PNL samples had more frequent histopathological alterations (epithelioid granulomas, mononuclear
infiltrates, fibrosis, perineurial and subperineurial oedema and decreased numbers of myelinated fibres) than
the NLN group. Multivariate analysis revealed that independently, mononuclear infiltrate and perineurial fibrosis
were more common in the PNL group and were able to correctly classify AFB-negative PNL samples. These results
indicate that even in the absence of AFB, these histopathological nerve alterations may justify a PNL diagnosis when
observed in conjunction with pertinent clinical, epidemiological and laboratory data. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Departamento de Patologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leprosy | pt_BR |
Subject | pure neural form | pt_BR |
Subject | Diagnosis | pt_BR |