Author | Savino, Wilson | |
Author | Smaniotto, Salete | |
Author | Cruz, Daniella Arêas Mendes da | |
Author | Dardenne, Mireille | |
Access date | 2016-09-12T16:46:29Z | |
Available date | 2016-09-12T16:46:29Z | |
Document date | 2012 | |
Citation | SAVINO, Wilson; et al. Growth hormone modulates migration of thymocytes and peripheral T cells. Annals of the New York Academy of Sciences, v.12621, n.1, p.49-54, 2012. | pt_BR |
ISSN | 0077-8923 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15758 | |
Language | eng | pt_BR |
Publisher | Wiley Online Library | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hormônio do Crescimento | pt_BR |
Subject in Portuguese | Timócitos | pt_BR |
Subject in Portuguese | Movimento Celular | pt_BR |
Subject in Portuguese | Integrinas | pt_BR |
Subject in Portuguese | Quimiocinas | pt_BR |
Subject in Portuguese | Linfonodos | pt_BR |
Title | Growth hormone modulates migration of thymocytes and peripheral T cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1749-6632.2012.06637.x | |
Abstract | In the context of immunoneuroendocrine cross talk, growth hormone (GH) exerts pleiotropic effects in the immune system. For example, GH-transgenic mice, as well as animals and humans treated with GH, exhibit enhanced cellularity in the thymus. GH also stimulates the thymic microenvironment, augmenting chemokine and extracellular matrix (ECM) production, with consequent increase in ECM- and chemokine-driven thymocyte migratory responses. Peripheral T cell migration triggered by laminin or fibronectin was enhanced in cells from GH-transgenic versus wild-type control adult mice, as seen for CD4(+) and CD8(+) T cells from mesenteric lymph nodes. Migration of these T lymphocytes, triggered by the chemokine CXCL12, in conjunction with laminin or fibronectin, was also enhanced compared with control counterparts. Considering that GH can be used as an adjuvant therapy in immunodeficiencies, including AIDS, the concepts defined herein, that GH enhances developing and peripheral T cell migration, provide new clues for future GH-related immune interventions. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil / Universidade Federal de Alagoas. Instituto de Ciências Biológicas e da Saúde. Laboratório de Imunohistologia. Maceió, AL, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. CNRS. Laboratório Internacional de Imunologia e Imunopatologia. Rio de Janeiro, RJ, Brasil / Université Paris Descartes. CNRS UMR-8147. Paris, France. | pt_BR |
Subject | Growth hormone | pt_BR |
Subject | Thymocites | pt_BR |
Subject | Cell migration | pt_BR |
Subject | Integrins | pt_BR |
Subject | Chemokines | pt_BR |
Subject | Lymph nodes | pt_BR |
Embargo date | 2020-01-01 | |