Author | Gripp, Carmem Beatriz Wagner Giacoia | |
Author | Sales, Anna Maria | |
Author | Nery, José Augusto da Costa | |
Author | Oliveira, Joanna Reis Santos de | |
Author | Oliveira, Ariane Leite de | |
Author | Sarno, Euzenir Nunes | |
Author | Morgado, Mariza Gonçalves | |
Access date | 2016-09-20T11:39:17Z | |
Available date | 2016-09-20T11:39:17Z | |
Document date | 2011 | |
Citation | GRIPP, Carmem Beatriz Wagner Giacoia; et al. Evaluation of cellular phenotypes implicated in immunopathogenesis and monitoring immune reconstitution inflammatory syndrome in HIV/Leprosy cases. Plos One, v.6, n.12, e28735, 8p, Dec. 2011. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15856 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Coinfecção por HIV | pt_BR |
Subject in Portuguese | Mycobacterium leprae | pt_BR |
Subject in Portuguese | Síndrome inflamatória de reconstituição imunológica | pt_BR |
Title | Evaluation of cellular phenotypes implicated in immunopathogenesis and monitoring immune reconstitution inflammatory syndrome in HIV/leprosy cases | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0028735 | |
Abstract | It is now evident that HAART-associated immunological improvement often leads to a variety of new clinical manifestations, collectively termed immune reconstitution inflammatory syndrome, or IRIS. This phenomenon has already been described in cases of HIV coinfection with Mycobacterium leprae, most of them belonging to the tuberculoid spectrum of leprosy disease, as observed in leprosy reversal reaction (RR). However, the events related to the pathogenesis of this association need to be clarified. This study investigated the immunological profile of HIV/leprosy patients, with special attention to the cellular activation status, to better understand the mechanisms related to IRIS/RR immunopathogenesis, identifying any potential biomarkers for IRIS/RR intercurrence. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | HIV | pt_BR |
Subject | Leprosy | pt_BR |
Subject | HIV coinfection | pt_BR |
Subject | Mycobacterium leprae | pt_BR |
Subject | Immune reconstitution inflammatory syndrome | pt_BR |