Author | Bello, Gonzalo | |
Author | Castro, Carlos A. Velasco de | |
Author | Bongertz, Vera | |
Author | Rodrigues, Caio A. Santos | |
Author | Giacoia-Gripp, Carmem B. W. | |
Author | Pilotto, Jose H. | |
Author | Grinsztejn, Beatriz | |
Author | Veloso, Valdiléa G. | |
Author | Morgado, Mariza G.binding antibodies | |
Access date | 2016-09-21T17:53:11Z | |
Available date | 2016-09-21T17:53:11Z | |
Document date | 2009 | |
Citation | BELLO, Gonzalo et al. Immune Activation and Antibody Responses in Non-Progressing Elite Controller Individuals Infected With HIV-1. Journal of Medical Virology, v. 81, p. 1681-1690, 2009. | pt_BR |
ISSN | 0146-6615 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/15893 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Controladores de HIV | pt_BR |
Subject in Portuguese | Progressores a longo prazo | pt_BR |
Subject in Portuguese | Ativação crônica | pt_BR |
Subject in Portuguese | Avidez do anticorpo | pt_BR |
Title | Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/jmv.21565 | |
Abstract | An extremely rare subset of patients infected with HIV-1 designated as "non-progressing elite controllers" appears to be able to maintain stable CD4(+) T-cell counts and a median plasma viremia below the detection limit of current ultrasensitive assays (<50-80 copies/ml of plasma) for >10 years in the absence of antiretroviral therapy. Lymphocyte subsets (CD4(+), CD8(+)), immune activation markers (HLA-DR(+), CD38(+), Beta-2-microglobulin), and HIV-specific antibody responses were longitudinally examined in four non-progressing elite controllers over more than 5 years. Two control groups of seronegative healthy individuals and untreated patients infected with HIV-1 presenting detectable viremia were also included. None of the non-progressing elite controllers displayed the high T-cell activation levels generally seen in the seropositive individuals, keeping them within the normal range. Three non-progressing elite controllers showed no significant immune system abnormalities when compared to seronegative individuals, displaying a low proportion of HIV-1-specific binding antibodies and low avidity index, similar to those observed for individuals infected recently with HIV-1. One non-progressing elite controller exhibited CD8(+) T-cell counts and beta2-M levels above normal ranges and developed a low but "mature" (high-avidity) HIV-1-specific antibody response. Thus, the non-progressing elite controllers are able to maintain normal T-cell activation levels, which may contribute to prevent, or greatly reduce, the damage of the immune system typically induced by the HIV-1 over time. They are, however, immunologically heterogeneous and very low levels of antigen exposure seem to occur in these patients, sufficient for sustaining a low, but detectable, HIV-1-specific immunity. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV controllers | pt_BR |
Subject | Long-term non-progressors | pt_BR |
Subject | Chronic activation | pt_BR |
Subject | Binding antibodies | pt_BR |
Subject | Antiboding avidity | pt_BR |
e-ISSN | 1096-9071 | |
Embargo date | 2030-01-01 | |