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ROLE OF ALTERNATIVE POLYADENYLATION DURING ADIPOGENIC DIFFERENTIATION: AN IN SILICO APPROACH
Adipogenic Differentiation
Mesenchymal stem cells
Afiliación
Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay / Universidad de la República. Facultad de Agronomía. Departamento de Producción Animal y Pasturas. Montevideo, Uruguay.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay / Universidad de la República. Facultad de Agronomía. Departamento de Producción Animal y Pasturas. Montevideo, Uruguay.
Resumen en ingles
Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post-transcriptional regulation mechanisms, such as alternative polyadenylation. This would involve changes in protein binding, transcript usage, miRNAs and other non-coding RNAs. In the present work we analyzed the distribution of alternative transcripts during adipogenic differentiation and the potential role of miRNAs in post-transcriptional regulation. Our in silico analysis suggests a modest, consistent, bias in 3′UTR lengths during differentiation enabling a fine-tuned transcript regulation via small non-coding RNAs. Including these effects in the analyses partially accounts for the observed discrepancies in relative abundance of protein and mRNA.
Palabras clave en ingles
Alternative PolyadenylationAdipogenic Differentiation
Mesenchymal stem cells
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