Autor | Spangenberg, Lucia | |
Autor | Dominguez, Alejandro Correa | |
Autor | Dallagiovanna, Bruno | |
Autor | Naya, Hugo | |
Data de acesso | 2016-09-30T17:12:37Z | |
Data de disponibilização | 2016-09-30T17:12:37Z | |
Data do publicação | 2013 | |
Citação | SPANGENBERG, Lucia et al. Role of alternative polyadenylation during adipogenic differentiation: an in silico approach. PLoS ONE, v. 8, n. 10, p. 1-13, 2013. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16017 | |
Fomento | Ministério da Saúde and Conselho Nacional de Desenvolvimento Cientıfico e Tecnologico-CNPq, FIOCRUZ, Pasteur Research Program and Fundação Araucaria. | pt_BR |
Idioma | eng | pt_BR |
Editor | Iratxe Puebla | pt_BR |
Direito Autoral | open access | pt_BR |
Título | Role of alternative polyadenylation during adipogenic differentiation: an in silico approach | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | 10.1371/journal.pone.0075578 | pt_BR |
Resumo em Inglês | Post-transcriptional regulation of stem cell differentiation is far from being completely understood. Changes in protein levels are not fully correlated with corresponding changes in mRNAs; the observed differences might be partially explained by post-transcriptional regulation mechanisms, such as alternative polyadenylation. This would involve changes in protein binding, transcript usage, miRNAs and other non-coding RNAs. In the present work we analyzed the distribution of alternative transcripts during adipogenic differentiation and the potential role of miRNAs in post-transcriptional regulation. Our in silico analysis suggests a modest, consistent, bias in 3′UTR lengths during differentiation enabling a fine-tuned transcript regulation via small non-coding RNAs. Including these effects in the analyses partially accounts for the observed discrepancies in relative abundance of protein and mRNA. | pt_BR |
Afiliação | Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. | pt_BR |
Afiliação | Institut Pasteur Montevideo. Bioinformatics Unit. Montevideo, Uruguay / Universidad de la República. Facultad de Agronomía. Departamento de Producción Animal y Pasturas. Montevideo, Uruguay. | pt_BR |
Palavras-chave em inglês | Alternative Polyadenylation | pt_BR |
Palavras-chave em inglês | Adipogenic Differentiation | pt_BR |
Palavras-chave em inglês | Mesenchymal stem cells | pt_BR |
DeCS | Poliadenilação | pt_BR |
DeCS | Diferenciação Celular | pt_BR |
DeCS | Células Mesenquimais Estromais | pt_BR |