Autor | Rossaneis, A. C. | |
Autor | Genaro, K. | |
Autor | Dias, Q. M. | |
Autor | Guethe, L. M. | |
Autor | Fais, R. S. | |
Autor | Del Bel, E. A. | |
Autor | Prado, Wiliam. A. | |
Data de acesso | 2016-11-30T19:13:07Z | |
Data de disponibilização | 2016-11-30T19:13:07Z | |
Data do publicação | 2015 | |
Citação | ROSSANEIS, A. C. et al. Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats. European Journal of Pain, London, v. 19, p. 1148-1157, Sept. 2015. | pt_BR |
ISSN | 1090-3801 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16393 | |
Idioma | eng | pt_BR |
Editor | European Journal of Pain | pt_BR |
Direito Autoral | restricted access | pt_BR |
Palavras-chave | Núcleo | pt_BR |
Palavras-chave | Neuropático | pt_BR |
Palavras-chave | Ratos | pt_BR |
Título | Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | DOI:10.1002/ejp.638 | |
Resumo em Inglês | Background: The anterior pretectal nucleus (APtN) activates descendingmechanisms of pain control. This study evaluated whether the APtN alsocontrols neuropathic pain in rats.Methods: The hypersensitivity to mechanical stimulation with anelectronic von Frey apparatus and the number of Fos-immunoreactive(Fos-ir) neurons in the APtN were evaluated in rats before and afterchronic constriction injury of the sciatic nerve.Results: The tactile hypersensitivity was characterized by an initial phase(the 2 days following the injury) and a maintenance phase (thesubsequent 7 days). The injection of 2% lidocaine (0.25 μL) orN-methyl-D-aspartate (2.5 μg/0.25 μL) into the APtN intensified thetactile hypersensitivity observed 2 days after injury but did not alter thetactile hypersensitivity observed 7 and 14 days after injury. The injection ofnaloxone (10 ng/0.25 μL) or methysergide (40 pg/0.25 μL) but notatropine (100 ng/0.25 μL) into the APtN also intensified the tactilehypersensitivity observed 2 days after the injury. A significant increase inthe number of Fos-ir cells was found in the contralateral APtN 2 days butnot 7 or 14 days after the injury. Electrical stimulation of the APtN reducedthe tactile hypersensitivity at 2, 7 and 14 days after the nerve ligation.Conclusion: APtN exerts a tonic inhibitory influence on persistent pain.The results point out to an important role of opioid and serotonergicmediation into the APtN to inhibit hyperalgesia during the initial phase ofneuropathic pain. | pt_BR |
Afiliação | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Afiliação | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Afiliação | Oswaldo Cruz Foundation, Fiocruz Rondônia, Porto Velho, RO, Brazil. | pt_BR |
Afiliação | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Afiliação | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Afiliação | Department of Morphology, Estomatology and Physiology, Faculty of Odontology of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Afiliação | Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. | pt_BR |
Palavras-chave em inglês | Nucleus | pt_BR |
Palavras-chave em inglês | Neuropathic | pt_BR |
Palavras-chave em inglês | Rats | pt_BR |