Author | Mol, Juliana P. S. | |
Author | Pires, Simone F. | |
Author | Chapeaurouge, Alexander D. | |
Author | Perales, Jonas | |
Author | Santos, Renato L. | |
Author | Andrade, Hélida M. | |
Author | Lage, Andrey P. | |
Access date | 2016-12-27T15:06:54Z | |
Available date | 2016-12-27T15:06:54Z | |
Document date | 2016 | |
Citation | MOL, Juliana P. S. et al. Proteomic Profile of Brucella abortus- Infected Bovine Chorioallantoic Membrane Explants. Plos One, v.11, n.4, e0154209, 16p, Apr. 2016. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16580 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Brucelose | pt_BR |
Subject in Portuguese | Perfil proteômico | pt_BR |
Subject in Portuguese | Membrana corioalantóica | pt_BR |
Subject in Portuguese | Bovinos | pt_BR |
Title | Proteomic Profile of Brucella abortus-Infected Bovine Chorioallantoic Membrane Explants | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0154209 | |
Abstract | Brucella abortus is the etiological agent of bovine brucellosis, a zoonotic disease that causes significant economic losses worldwide. The differential proteomic profile of bovine chorioallantoic membrane (CAM) explants at early stages of infection with B. abortus (0.5, 2, 4, and 8 h) was determined. Analysis of CAM explants at 0.5 and 4 h showed the highest differences between uninfected and infected CAM explants, and therefore were used for the Differential Gel Electrophoresis (DIGE). A total of 103 spots were present in only one experimental group and were selected for identification by mass spectrometry (MALDI/ToF-ToF). Proteins only identified in extracts of CAM explants infected with B. abortus were related to recognition of PAMPs by TLR, production of reactive oxygen species, intracellular trafficking, and inflammation. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Medicina Veterinária Preventiva. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Parasitologia. Belo Horizonte,MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Parasitologia. Belo Horizonte,MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Medicina Veterinária Preventiva. Belo Horizonte, MG, Brasil. | pt_BR |
Subject | Brucella abortus | pt_BR |
Subject | Proteomic Profile | pt_BR |
Subject | bovine chorioallantoic membrane (CAM) | pt_BR |