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https://www.arca.fiocruz.br/handle/icict/16602
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-01-01
Coleções
- IOC - Artigos de Periódicos [12500]
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THE GATA3 GENE IS INVOLVED IN LEPROSY SUSCEPTIBILITY IN BRAZILIAN PATIENTS
GATA3
Polymorphism
Association study
GATA-3 transcription factor
rs10905284
Autor(es)
Afiliação
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Instituto Lauro de Souza Lima, ILSL. Bauru, SP, Brasil.
Resumo em Inglês
Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.
Palavras-chave em inglês
LeprosyGATA3
Polymorphism
Association study
GATA-3 transcription factor
rs10905284
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