Author | Correa, Claudia Maria Nogueira | |
Author | Sudo, Gisele Zapata | |
Author | Sudo, Roberto Takashi | |
Access date | 2011-03-23T21:02:20Z | |
Available date | 2011-03-23T21:02:20Z | |
Document date | 2010 | |
Citation | CORREA, Claudia Maria Nogueira; SUDO, Gisele Zapata; SUDO, Roberto Takashi. Efeitos hemodinâmicos do atracúrio e do cisatracúrio e o uso de difenidramina e cimetidina. Revista Brasileira de Anestesiologia, Rio de Janeiro, v. 60, n. 1, p. 52-63, jan./fev. 2010. | pt_BR |
ISSN | 1806-907X | |
URI | https://www.arca.fiocruz.br/handle/icict/1734 | |
Abstract in Portuguese | JUSTIFICATIVA E OBJETIVOS: Haja visto que atracúrio pode causar hipotensão arterial no homem, investigaram-se os efeitos hemodinâmicos promovidos pelo atracúrio e pelo cisatracúrio e a proteção hemodinâmica conferida pela difenidramina e cimetidina em ratos. MÉTODO: 1) Ratos Wistar anestesiados com pentobarbital sódico e preparados de acordo com Brown e col. para avaliar doses de atracúrio e cisatracúrio para redução de T4/T1 da sequência de quatro estímulos maior ou igual a 95%. 2) Avaliação das alterações hemodinâmicas de atracúrio e cisatracúrio por injeção venosa, medindo-se a pressão arterial sistêmica da artéria carótida e eletrocardiograma de ratos. 3) Observação de proteção hemodinâmica pelo tratamento prévio com difenidramina (2 mg.kg-1) e/ou cimetidina (4 mg.kg -1) por injeção venosa. Análise estatística: teste t de Student, ANOVA. RESULTADOS: O atracúrio e o cisatracúrio não modificaram a pressão arterial média (PAM) nas doses de 1 mg.kg -1 e 0,25 mg.kg -1, respectivamente. Doses de 4 mg.kg -1 promoveram diminuição da PAM de 62,8 ± 4,5% do controle para o atracúrio, e de 82,5 ± 2,3% do controle para o cisatracúrio. Com difenidramina e cimetidina, a pressão sistólica diminuiu 95,4 ± 2,5% do controle. Com cimetidina, pressão diastólica diminuiu 82,7 ± 8,4% do controle. O efeito conjunto sobre as pressões sistólica e diastólica refletiu-se nos valores observados da PAM. CONCLUSÕES: A difenidramina e a cimetidina, isoladamente, não impediram a diminuição da pressão arterial média induzida pelo atracúrio. No entanto, associação destes dois fármacos foi eficaz na prevenção dos efeitos hemodinâmicos induzidos pelo atracúrio. O cisatracúrio nas doses do experimento não promoveu diminuição da pressão arterial que justificasse as medidas preventivas aplicadas nos grupos onde se utilizou o atracúrio. | pt_BR |
Language | por | pt_BR |
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Rights | open access | pt_BR |
Subject in Portuguese | Ratos | |
Subject in Portuguese | Bloqueadores Neuromusculares | |
Subject in Portuguese | Cimetidina | |
Subject in Portuguese | Difenidramina | |
Title | Efeitos hemodinâmicos do atracúrio e do cisatracúrio e o uso de difenidramina e cimetidina | pt_BR |
Alternative title | Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine | pt_BR |
Alternative title | Efectos hemodinámicos del atracurio y del cisatracurio y el uso de la difenidramina y la cimetidina | |
Type | Article | pt_BR |
DOI | 10.1590/S0034-70942010000100006 | |
Abstract | BACKGROUND AND OBJECTIVES: Since atracurium can cause hypotension in humans, the hemodynamic effects of atracurium and cisatracurium as well as the hemodynamic protection of diphenhydramine and cimetidine were investigated in rats. METHODS: 1) Wistar rats were anesthetized with sodium pentobarbital and prepared according to Brown et al. to evaluate different doses of atracurium and cisatracurium in the reduction of T4/T1 equal or greater than 95%. 2) Assessment of the hemodynamic changes caused by the intravenous administration of atracurium and cisatracurium by monitoring the blood pressure in the carotid artery and the electrocardiogram of rats. 3) Observation of the hemodynamic protection of prior treatment with the intravenous administration of diphenhydramine (2 mg.kg-1) and/or cimetidine (4 mg.kg-1). Statistical analysis: Student t test and ANOVA. RESULTS: Doses of 1 mg.kg-1 and 0.25 mg.kg-1 of atracurium and cisatracurium respectively did not change the mean arterial pressure (MAP). Doses of 4 mg.kg-1 of atracurium and cisatracurium decreased MAP to 62.8 ± 4.5% and 82.5 ± 2.3% respectively when compared to control levels. When the rats were pre-treated with diphenhydramine and cimetidine, diastolic pressure was reduced to 95.4% ± 2.5%. With cimetidine, diastolic pressure was reduced to 82.7 ± 8.4% when compared to the control group. The effects on systolic and diastolic blood pressure were reflected in the levels of MAP. CONCLUSIONS: The isolated administration of diphenhydramine and cimetidine did not prevent the reduction in mean arterial pressure induced by atracurium. However, the association of both drugs was able to prevent the hemodynamic effects of atracurium. The doses of cisatracurium used in this study did not cause a reduction in blood pressure significant enough to justify the use of the preventive measures used in the atracurium groups. | pt_BR |
xmlui.metadata.dc.description.abstractes | JUSTIFICATIVA Y OBJETIVOS: Habida cuenta de que el atracurio puede causar hipotensión arterial en el hombre, se investigaron los efectos hemodinámicos promovidos por el atracurio y por el cisatracurio, y la protección hemodinámica dada por la difenidramina y la cimetidina en ratones. MÉTODO: 1) Ratones Wistar anestesiados con pentobarbital sódico y preparados de acuerdo con Brown y col. para evaluar las dosis de atracurio y cisatracurio para la reducción de T4/T1 de la secuencia de cuatro estímulos mayor o igual al 95%. 2) Evaluación de las alteraciones hemodinámicas del atracurio y el cisatracurio por inyección venosa, midiendo la presión arterial sistémica de la arteria carótida y electrocardiograma de ratones. 3) Observación de la protección hemodinámica por el tratamiento previo con difenidramina (2 mg.kg-1) y/o cimetidina (4 mg.kg-1) por inyección venosa. Análisis estadístico: test t de Student, ANOVA. RESULTADOS: El atracurio y el cisatracurio no modificaron la presión arterial promedio (PAP) en las dosis de 1 mg.kg-1 y 0,25 mg.kg-1, respectivamente. Las dosis de 4 mg.kg-1 disminuyeron la PAP de 62,8 ± 4,5% del control para el atracurio, y de 82,5 ± 2,3% del control para el cisatracurio. Con la difenidramina y la cimetidina, la presión sistólica se redujo a 95,4 ± 2,5% del control. Con la cimetidina, la presión diastólica disminuyó 82,7 ± 8,4% del control. El efecto con-junto sobre las presiones sistólica y diastólica se reflejó en los valores observados de la PAP. CONCLUSIONES: La difenidramina y la cimetidina, aisladamente, no impidieron la disminución de la presión arterial promedio inducida por el atracurio. Sin embargo, la asociación de esos de los fármacos fue eficaz en la prevención de los efectos hemodinámicos inducidos por el atracurio. El cisatracurio, en las dosis del experimento, no promovió una disminución de la presión arterial que justificase las medidas preventivas aplicadas en los grupos donde se utilizó el atracurio. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Rats | |
Subject | Neuromuscular Blockers | |
Subject | Cimetidine | |
Subject | Diphenhydramine | |
DeCS | Difenidramina | |
DeCS | Hemodinâmica | |
DeCS | Agentes não Despolarizantes Neuromusculares | |
DeCS | Atracúrio | |
DeCS | Cimetidina | |
DeCS | Ratos Wistar | |