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ROLE OF LTA4H POLYMORPHISM IN TUBERCULOSIS-ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME OCCURRENCE AND CLINICAL SEVERITY IN PATIENTS INFECTED WITH HIV
HIV
Humanos
Inflamação
Polimorfismo
Síndrome inflamatória da reconstituição imune
HIV
Human
Inflammation
Polymorphism
Immune reconstitution inflammatory syndrome
Autor
Narendran, Gopalan
Kavitha, Dhanasekaran
Karunaianantham, Ramesh
Santana, Leonardo Gil
Almeida Junior, Jilson Leão de
Reddy, Sirasanambatti Devarajulu
Kumar, Marimuthu Makesh
Hemalatha, Haribabu
Jayanthi, Nagesh Nalini
Ravichandran, Narayanan
Krishnaraja, Raja
Prabhakar, Angamuthu
Manoharan, Tamizhselvan
Nithyananthan, Lokeswaran
Arjunan, Gunasundari
Natrajan, Mohan
Swaminathan, Soumya
Andrade, Bruno de Bezerril
Kavitha, Dhanasekaran
Karunaianantham, Ramesh
Santana, Leonardo Gil
Almeida Junior, Jilson Leão de
Reddy, Sirasanambatti Devarajulu
Kumar, Marimuthu Makesh
Hemalatha, Haribabu
Jayanthi, Nagesh Nalini
Ravichandran, Narayanan
Krishnaraja, Raja
Prabhakar, Angamuthu
Manoharan, Tamizhselvan
Nithyananthan, Lokeswaran
Arjunan, Gunasundari
Natrajan, Mohan
Swaminathan, Soumya
Andrade, Bruno de Bezerril
Afiliación
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Vellore Medical College and Hospital. Vellore, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India / India Council of Medical Research. Department of Health Research Ministry of Health and FamilyWelfare. Health secretary. New Delhi, India
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India
Government Vellore Medical College and Hospital. Vellore, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India
National Institute for Research in Tuberculosis. Chennai, India / India Council of Medical Research. Department of Health Research Ministry of Health and FamilyWelfare. Health secretary. New Delhi, India
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil
Resumen en ingles
Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide polymorphism (SNP) in the LTA4H promoter which regulates its transcriptional activity (rs17525495) has been identified and described to impact clinical severity of TB presentation and response to corticosteroid therapy. Notably, the role of LTA4H on TB-IRIS has not been previously evaluated. Here, we performed an exploratory investigation testing the association of LTA4H polymorphism with respect to frequency of TB-IRIS occurrence and severity of TB-IRIS presentation in HIV-TB co-infected individuals.
Palabras clave en portugues
TuberculoseHIV
Humanos
Inflamação
Polimorfismo
Síndrome inflamatória da reconstituição imune
Palabras clave en ingles
TuberculosisHIV
Human
Inflammation
Polymorphism
Immune reconstitution inflammatory syndrome
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