Author | Narendran, Gopalan | |
Author | Kavitha, Dhanasekaran | |
Author | Karunaianantham, Ramesh | |
Author | Santana, Leonardo Gil | |
Author | Almeida Junior, Jilson Leão de | |
Author | Reddy, Sirasanambatti Devarajulu | |
Author | Kumar, Marimuthu Makesh | |
Author | Hemalatha, Haribabu | |
Author | Jayanthi, Nagesh Nalini | |
Author | Ravichandran, Narayanan | |
Author | Krishnaraja, Raja | |
Author | Prabhakar, Angamuthu | |
Author | Manoharan, Tamizhselvan | |
Author | Nithyananthan, Lokeswaran | |
Author | Arjunan, Gunasundari | |
Author | Natrajan, Mohan | |
Author | Swaminathan, Soumya | |
Author | Andrade, Bruno de Bezerril | |
Access date | 2017-02-09T12:52:12Z | |
Available date | 2017-02-09T12:52:12Z | |
Document date | 2016 | |
Citation | NARENDRAN, G. et al. Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV. Plos One, v. 11, n. 9, p. e0163298, 2016. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17764 | |
Sponsorship | Intramuralto-India Program, NIAID, NIH, USA and by the Indian Council of Medical Research, India. Fundação de Amparo à Pesquisa do Estado da Bahia / Fundação Oswaldo Cruz, Brazil. | pt_BR |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | Humanos | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Polimorfismo | pt_BR |
Subject in Portuguese | Síndrome inflamatória da reconstituição imune | pt_BR |
Title | Role of LTA4H Polymorphism in Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Occurrence and Clinical Severity in Patients Infected with HIV | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0163298 | |
Abstract | Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory phenomenon complicating HIV management in coincidental tuberculosis (TB) infection, upon immune reconstitution driven by antiretroviral therapy (ART). Leukotriene A4 hydroxylase (LTA4H), an enzyme which converts LTA4 to LTB4, regulates the balance between the anti-inflammatory lipoxins and pro-inflammatory LTB4, with direct implications in TB-driven inflammation. In humans, a single nucleotide polymorphism (SNP) in the LTA4H promoter which regulates its transcriptional activity (rs17525495) has been identified and described to impact clinical severity of TB presentation and response to corticosteroid therapy. Notably, the role of LTA4H on TB-IRIS has not been previously evaluated. Here, we performed an exploratory investigation testing the association of LTA4H polymorphism with respect to frequency of TB-IRIS occurrence and severity of TB-IRIS presentation in HIV-TB co-infected individuals. | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India | pt_BR |
Affilliation | Government Hospital of Thoracic Medicine. Tambaram Sanatorium, Chennai, India | pt_BR |
Affilliation | Government Vellore Medical College and Hospital. Vellore, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India | pt_BR |
Affilliation | National Institute for Research in Tuberculosis. Chennai, India / India Council of Medical Research. Department of Health Research Ministry of Health and FamilyWelfare. Health secretary. New Delhi, India | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunorregulação. Unidade de Medicina Investigativa. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network SponsoringTranslational and Epidemiological Research (MONSTER) Initiative. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | HIV | pt_BR |
Subject | Human | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Polymorphism | pt_BR |
Subject | Immune reconstitution inflammatory syndrome | pt_BR |