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https://www.arca.fiocruz.br/handle/icict/17788
RECOMBINATION IN PE/PPE GENES CONTRIBUTES TO GENETIC VARIATION IN MYCOBACTERIUM TUBERCULOSIS LINEAGES
Genoma, Bacteriano
Genomica
Evolução, Molecular
DNA, Bacteriana
Análise de Seqüência, DNA
Genes, Bacteriana
Genome, Bacterial
Genomics
Evolution, Molecular
DNA, Bacterial
Sequence Analysis, DNA
Genes, Bacteriano
Author
Phelan, Jody E
Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
Coll, Francesc
Bergval, Indra
Anthony, Richard M
Warren, Rob
Sampson, Samantha L
Gey van Pittius, Nicolaas C
Glynn, Judith R
Crampin, Amelia C
Alves, Adriana
Bessa, Theolis Costa Barbosa
Campino, Susana
Dheda, Keertan
Grandjean, Louis
Hasan, Rumina
Hasan, Zahra
Miranda, Anabela
Moore, David
Panaiotov, Stefan
Perdigao, Joao
Portugal, Isabel
Sheen, Patricia
Sousa, Erivelton de Oliveira
Streicher, Elizabeth M
van Helden, Paul D
Viveiros, Miguel
Hibberd, Martin L
Pain, Arnab
McNerney, Ruth
Clark, Taane G
Affilliation
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands
Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK
London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK / Karonga Prevention Study. Lilongwe, Malawi.
National Mycobacterium Reference Laboratory. Porto, Portugal
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
University of Cape Town. Department of Medicine, Lung Infection and Immunity Unit. Division of Pulmonology & UCT Lung Institute. Cape Town, Western Cape, South Africa / University of Cape Town. Institute of Infectious Diseases and Molecular Medicine. Cape Town, Western Cape, South Africa
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru
The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan
The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan
National Mycobacterium Reference Laboratory. Porto, Portugal
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
Universidade de Lisboa. Lisbon, Portugal
Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands
Royal Tropical Institute. KIT Biomedical Research. Amsterdam, Netherlands
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, and Medical Research Council Centre for Molecular and Cellular Biology. Division of Molecular Biology and Human Genetics. Tygerberg, South Africa.
London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK
London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK / Karonga Prevention Study. Lilongwe, Malawi.
National Mycobacterium Reference Laboratory. Porto, Portugal
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
University of Cape Town. Department of Medicine, Lung Infection and Immunity Unit. Division of Pulmonology & UCT Lung Institute. Cape Town, Western Cape, South Africa / University of Cape Town. Institute of Infectious Diseases and Molecular Medicine. Cape Town, Western Cape, South Africa
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru
The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan
The Aga Khan University, Stadium Road. Department of Pathology and Laboratory Medicine. Karachi, Pakistan
National Mycobacterium Reference Laboratory. Porto, Portugal
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
National Center of Infectious and Parasitic Diseases. Sofia, Bulgaria
Universidade de Lisboa. Lisbon, Portugal
Universidad Peruana Cayetano Heredia. Facultad de Ciencias y Filosofía. Laboratorio de Enfermedades Infecciosas. Laboratorios de Investigación y Desarrollo. Lima, Peru
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel
London School of Hygiene & Tropical Medicine. Faculty of Infectious and Tropical Diseases Department of Pathogen. Molecular Biology. Keppel / London School of Hygiene & Tropical Medicine. Faculty of Epidemiology and Population Health. London, UK
Abstract
Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important virulence factors involved with host-pathogen interactions, but their high genetic variability and complexity of analysis means they are typically disregarded in genome studies.
Keywords in Portuguese
Mycobacterium tuberculosisGenoma, Bacteriano
Genomica
Evolução, Molecular
DNA, Bacteriana
Análise de Seqüência, DNA
Genes, Bacteriana
Keywords
Mycobacterium tuberculosisGenome, Bacterial
Genomics
Evolution, Molecular
DNA, Bacterial
Sequence Analysis, DNA
Genes, Bacteriano
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