Author | Elias, Paula Regina | |
Author | Coelho, Gleicekelly Silva | |
Author | Xavier, Viviane Flores | |
Author | Sales Junior, Policarpo Ademar | |
Author | Romanha, Alvaro José | |
Author | Murta, Silvane Maria Fonseca | |
Author | Carneiro, Claudia Martins | |
Author | Camilo, Nilton Soares | |
Author | Hilário, Flaviane Francisco | |
Author | Taylor, Jason Guy | |
Access date | 2017-02-14T17:48:24Z | |
Available date | 2017-02-14T17:48:24Z | |
Document date | 2016 | |
Citation | ELIAS, et al. Paula Regina Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity. Molecules, v. 21, n. 10, art. E1342, 2016. | pt_BR |
ISSN | 1420-3049 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17813 | |
Language | eng | pt_BR |
Publisher | MDPI | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | amastigote | pt_BR |
Subject in Portuguese | Doença de chagas | pt_BR |
Title | Synthesis of Xylitan Derivatives and Preliminary Evaluation of in Vitro Trypanocidal Activity. | pt_BR |
Type | Article | pt_BR |
DOI | 10.3390/molecules21101342 | |
Abstract | A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells. The arylsulfonate xylitan derivative bearing a nitro group displayed the best activity of all the compounds tested, and was slightly more potent than the reference drug benznidazole. The importance of the isopropylidene ketal moiety was established and the greater lipophilicity of these compounds suggests enhancement in cell penetration. | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Quimica. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Quimica. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Quimica. Ouro Preto, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Núcleo de Pesquisas em Ciências Biológicas. Laboratorio de Imunopatologia. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Estadual de Campinas. Instituto de Química. Campinas, SP, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Quimica. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Quimica. Ouro Preto, MG, Brazil | pt_BR |
Subject | amastigote | pt_BR |
Subject | anhydropentitol | pt_BR |
Subject | chagas disease | pt_BR |
Subject | in vitro | pt_BR |
Subject | trypomastigote | pt_BR |
Subject | xylitan | pt_BR |
Subject | xylitol | pt_BR |
Embargo date | 2025-01-01 | |