Author | Romão, Raquel Peralva Ribeiro | |
Author | Saavedra, Andrea Franco | |
Author | Cruz, Alda Maria da | |
Author | Pinto, Eduardo Fonseca | |
Author | Moreira, Otacilio C. | |
Access date | 2017-02-23T15:48:47Z | |
Available date | 2017-02-23T15:48:47Z | |
Document date | 2016 | |
Citation | ROMÃO, Raquel Peralva Ribeiro; et al.Development of real-time PCR assays for evaluation of immune response and parasite load in golden hamster (Mesocricetus auratus) infected by Leishmania (Viannia) braziliensis. Parasites & Vectors, v.9:361, 12p, 2016. | pt_BR |
ISSN | 1756-3305 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/17893 | |
Language | eng | pt_BR |
Publisher | BioMed Central | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Reação em Cadeia da Polimerase | pt_BR |
Subject in Portuguese | Carga parasitária | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Subject in Portuguese | Hamster | pt_BR |
Title | Development of real-time PCR assays for evaluation of immune response and parasite load in golden hamster (Mesocricetus auratus) infected by Leishmania (Viannia) braziliensis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/s13071-016-1647-6 | |
Abstract | Cutaneous leishmaniasis (CL) is a neglected disease with a broad spectrum of clinical manifestations, ranging from small cutaneous nodules to severe mucosal tissue destruction. Leishmania (Viannia) braziliensis is the main species attributed to CL in the Americas. However, studies of experimental infection are limited in the murine model due to the self-resolutive pattern of the disease. Previously, our group demonstrated that the hamster model reproduces many of the clinical and histopathological features observed in humans. Herein, we standardized a RT-qPCR gene expression assay to evaluate a panel of immunological markers and a qPCR assay in order to quantify with high sensitivity and reproducibility the parasite load in skin lesions. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | real-time PCR | pt_BR |
Subject | golden hamster | pt_BR |
Subject | immune response | pt_BR |
Subject | parasite load | pt_BR |
Subject | Leishmania (Viannia) braziliensis | pt_BR |