Author | Amoussa, Adjile Edjide Roukiyath | |
Author | Wilkinson, Eduan | |
Author | Giovanetti, Marta | |
Author | Rego, Filipe Ferreira de Almeida | |
Author | Araujo, Thessika Hialla Almeida | |
Author | Gonçalves, Marilda de Souza | |
Author | Oliveira, Tulio de | |
Author | Alcantara, Luiz Carlos Júnior | |
Access date | 2017-03-14T16:30:50Z | |
Available date | 2017-03-14T16:30:50Z | |
Document date | 2017 | |
Citation | AMOUSSA, A. E. R. et al. HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade. Infection, Genetics and Evolution, v. 48, p. 95–101, 2017. | pt_BR |
ISSN | 1567-1348 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18035 | |
Sponsorship | CNPq (200328/2015-8) Conselho Nacional de Desenvolvimento Científico e Tecnológico - Brasil. E.W.
and T.d.O are funded by a Medical Research Council flagship grant of the Republic of South Africa (MRC-RFA-UFSP-01-2013/UKZN HIVEPI) | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | África do Sul | pt_BR |
Subject in Portuguese | Escravos | pt_BR |
Title | HTLV-1aA introduction into Brazil and its association with the trans-Atlantic slave trade | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.meegid.2016.12.005 | |
Abstract | Human T-lymphotropic virus (HTLV) is an endemic virus in some parts of the world, with Africa being home to most of the viral genetic diversity. In Brazil, HTLV-1 is endemic amongst Japanese and African immigrant populations. Multiple introductions of the virus in Brazil from other epidemic foci were hypothesized. The long terminal repeat (LTR) region of HTLV-1 was used to infer the origin of the virus in Brazil, using phylogenetic analysis. Methods: LTR sequences were obtained from the HTLV-1 database (http://htlv1db.bahia.fiocruz.br). Sequences
were aligned and maximum-likelihood and Bayesian tree topologies were inferred. Brazilian specific clusters
were identified and molecular-clock and coalescent models were used to estimate each cluster's time to the
most recent common ancestor (tMRCA).
Results: Three Brazilian clusters were identified with a posterior probability ranged from 0.61 to 0.99. Molecular
clock analysis of these three clusters dated back their respective tMRCAs between the year 1499 and the year
1668. Additional analysis also identified a close association between Brazilian sequences and new sequences
from South Africa.
Conclusion: Our results support the hypothesis of amultiple introductions of HTLV-1 into Brazil,with the majority
of introductions occurring in the post-Colombian period. Our results further suggest that HTLV-1 introduction
into Brazil was facilitated by the trans-Atlantic slave trade fromendemic areas of Africa. The close association between
southern African and Brazilian sequences also suggested that greater numbers of the southern African
Bantu population might also have been part of the slave trade than previously though | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Kwazulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / University of Rome “Tor Vergata”. Italy | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Catholic University of Salvador. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil / Bahia School of Medicine and Public Health. Bahia Foundation for Development of Science. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Kwazulu-Natal. Africa Centre for Health and Population Studies. Durban, South Africa | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Brazil | pt_BR |
Subject | Southern Africa | pt_BR |
Subject | Trans-Atlantic slave trade | pt_BR |