Author | Figueiredo, Camylla Vilas Boas | |
Author | Carvalho, Magda Oliveira Seixas | |
Author | Santiago, Rayra Pereira | |
Author | Santana, Sânzio Silva | |
Author | Oliveira, Rodrigo Mota de | |
Author | Fiuza, Luciana Magalhães | |
Author | Guarda, Caroline Conceição da | |
Author | Aleluia, Milena Magalhães | |
Author | Nascimento, Valma Maria Lopes do | |
Author | Lyra, Isa Menezes | |
Author | Ferreira, Júnia Raquel Dutra | |
Author | Goncalves, Marilda de Souza | |
Access date | 2017-03-20T17:41:54Z | |
Available date | 2017-03-20T17:41:54Z | |
Document date | 2016 | |
Citation | FIGUEIREDO, C. V. B. et al. Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease. Meta Gene, v. 10, p. 27–31, 2016 | pt_BR |
ISSN | 2214-5400 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18082 | |
Sponsorship | Brazilian National Council of Research (CNPq) (3065427/2007-5 and 484457/2007-1) (M.S.G.); the Foundation of Research and Extension of Bahia (FAPESB) (1431040053063 and 9073/2007) (M.S.G.); and MCD/CNPq/MS-SCTIE-DECIT (409800/2006-6), (M.S.G.). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Doença falciforme | pt_BR |
Subject in Portuguese | Leptin | pt_BR |
Subject in Portuguese | TGF-β | pt_BR |
Subject in Portuguese | Polimorfismo gênico | pt_BR |
Title | Leptin − 2548 G > A gene polymorphism is associated with lipids metabolism and TGF-β alteration in sickle cell disease | pt_BR |
Type | Article | pt_BR |
Abstract | Background: Leptin is a proteinwith regulatory role in several body systems such as the immune system, and energy
balance. Given that patients with sickle cell disease (SCD) have changes in cellular immunity and lipid metabolism,
it is important to conduct research aimed understand the role of leptin in the pathophysiology of SCD.
Results:We studied 103 patients with SCD from Northeast of Brazil in a case-control study. The investigation of
the leptin −2548 G N A polymorphism in SCD individuals shows the frequency of 60.20% (62/103) for the wild
genotype (GG); 34.95% (36/103) for the heterozygous genotype (AG) and 4.85% (5/103) for the variant homozygote
genotype (AA). In the healthy volunteers group the polymorphism investigation indicated the frequency of
58.24% (53/91) for the wild genotype (GG); 37.36% (34/91) for the heterozygous genotype (AG) and 4.40% (4/
91) for the variant homozygote genotype (AA). The AA genotype was associated with increased levels of verylow-
density lipoprotein cholesterol (VLDL-C) and triglycerides among SCD patients. Furthermore, the presence
of allele A was associated with the highest levels of transforming growth factor beta (TGF-β) in SCD patients.
Conclusion: The results suggest that the presence of the variant allele may influence the disturbances in lipidmetabolism
and serum levels of TGF-β described in SCD patients. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil | pt_BR |
Affilliation | Complexo Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil / Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Subject | Sickle cell disease | pt_BR |
Subject | Leptin | pt_BR |
Subject | TGF-β | pt_BR |
Subject | Gene polymorphism | pt_BR |