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Autor | Santos, Luciana Nahar dos | |
Autor | Silva, Pedro Henrique Lopes da | |
Autor | Alvim, Iris Maria Peixoto | |
Autor | Nery, José Augusto da Costa | |
Autor | Lara, Flavio Alves | |
Autor | Sarno, Euzenir Nunes | |
Autor | Esquenazi, Danuza | |
Fecha de acceso | 2017-03-21T13:12:08Z | |
Fecha de disponibilización | 2017-03-21T13:12:08Z | |
Fecha de publicación | 2016 | |
Referencia | SANTOS, Luciana Nahar dos; et al. Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients. Plos One, v.11, n.10, e0164543, 19p, Oct. 2016. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18094 | |
Idioma | eng | pt_BR |
Editor | Public Library of Science | pt_BR |
Derechos de autor | open access | |
Palabras clave en Portugués | Hanseníase | pt_BR |
Palabras clave en Portugués | Mycobacterium leprae | pt_BR |
Palabras clave en Portugués | Células T citotóxicas | pt_BR |
Palabras clave en Portugués | Expressão genetica | pt_BR |
Palabras clave en Portugués | Inflamação | pt_BR |
Palabras clave en Portugués | Lesões | pt_BR |
Título | Role of Teffector/Memory Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients | pt_BR |
Tipo del documento | Article | |
DOI | 10.1371/journal.pone.0164543 | |
Resumen en Inglés | In spite of hyporesponsivity to Mycobacterium leprae, borderline lepromatous (BL) patients show clinical and immunological instability, and undergo frequent acute inflammatory episodes such as type 1 reaction (T1R), which may cause nerve damages. This work focused on the participation of T cell subsets from blood and skin at T1R onset. We observed a significantly increased ex vivo frequency of both effector and memory CD4+ and CD8+ T cells in T1R group. Besides, ex vivo frequency of T cell homing receptor, the Cutaneous Leukocyte-associated Antigen (CLA) was significantly increased in T cells from T1R patients. M. leprae induced a higher frequency of CD4+ TEM and CD8+ TEF cells, as well as of CD8+/TEMRA (terminally differentiated effector T cells) subset, which expressed high CD69+. The presence of IFN-γ‒producing-CD4+ TEF and naïve and effector CD8+ T lymphocytes was significant in T1R. TBX21 expression was significantly higher in T1R, while BL showed increased GATA3 and FOXP3 expression. In T1R, TBX21 expression was strongly correlated with CD8+/IFN-γ‒ T cells frequency. The number of double positive CD8+/CLA+ and CD45RA+/CLA+ cells was significantly higher in skin lesions from T1R, in comparison with non-reactional BL group. The observed increase of ex vivo T cells at T1R onset suggests intravascular activation at the beginning of reactional episodes. The antigen-specific response in T1R group confirmed the higher number of CD8+/CLA+ and CD45RA+/CLA+ cells in T1R lesions suggests possible migration of these cells activated by M. leprae components inside the vascular compartment to skin and participation in T1R physiopathology. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil / Universidade do Estado do Rio de Janeiro. Escola de Ciências Mèdicas. Departamento de Patologia e Laboratórios. Rio de Janeiro, RJ, Brasil. | pt_BR |
Palavras clave en Inglês | Leprosy | pt_BR |
Palavras clave en Inglês | Cytotoxic T cells | pt_BR |
Palavras clave en Inglês | Mycobacterium leprae | pt_BR |
Palavras clave en Inglês | Gene expression | pt_BR |
Palavras clave en Inglês | Inflamation | pt_BR |
Palavras clave en Inglês | Lesions | pt_BR |
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