Author | Raboni, Sonia M. | |
Author | Bonfim, Carmem | |
Author | Almeida, Bernardo M. | |
Author | Zanluca, Camila | |
Author | Koishi, Andrea Cristine | |
Author | Rodrigues, Paula R. V. P. | |
Author | Kay, Claudia K. | |
Author | Ribeiro, Lisandro L. | |
Author | Scola, Rosana H. | |
Author | Duarte Dos Santos, Claudia N. | |
Access date | 2017-03-29T19:41:05Z | |
Available date | 2017-03-29T19:41:05Z | |
Document date | 2017 | |
Citation | Raboni, Sonia M. etal. Flavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: A case report. Transplant Infectious Disease, p. 1-14, Mar. 2017 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18202 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Virus da Dengue | pt_BR |
Subject in Portuguese | Zika Virus | pt_BR |
Subject in Portuguese | Síndrome de Guillain Barre | pt_BR |
Title | Flavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: a case report | pt_BR |
Type | Preprint | pt_BR |
DOI | 10.1111/tid.12700 | |
Abstract | Serological diagnosis of flavivirus infection is a challenge, particularly in the context of a disease associated with immune response enhancement in a transplant patient, where aspects such as previous flavivirus infections may be involved with the outcome. We report a case of a pediatric patient who developed Guillain-Barré syndrome (GBS) after matched-unrelated hematopoietic stem cell transplantation (HSCT). The patient lives in a Brazilian region that is experiencing an epidemic of Zika virus (ZIKV) and dengue virus (DENV). Because an increasing number of cases of GBS, likely triggered by ZIKV infection, are being reported in Brazil, samples from the patient were tested for both ZIKV and DENV infection. Serological assays strongly suggested a recent ZIKV infection, although infection by DENV or co-infection with both viruses cannot be ruled out. The presence of anti-DENV immunoglobulin-G in donor serum led to the hypothesis that antibodies from the donor could have enhanced the severity of the ZIKV infection. This hypothesis is in agreement with the recent findings that DENV sero-cross-reactivity drives antibody-dependent enhancement of ZIKV infection. These findings highlight the need for discussion of the indication to perform previous flavivirus tests in HSCT donors, especially in areas where ZIKV and other flaviviruses co-circulate. This article is protected by copyright. All rights reserved. | pt_BR |
Affilliation | Universidade Federal do Paraná. Laboratório de Virologia. Paraná, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Hospital de Epidemiologia. Paraná, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Divisão de Transplantes. Paraná, PR, Brasil. | pt_BR |
Affilliation | Universidade Federal do Paraná. Divisão de Neurologia. Serviço de Doença Neuromuscular. Paraná, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Guillain-Barré Syndrome | pt_BR |
Subject | Dengue Virus | pt_BR |
Subject | Hematopoietic Stem Cell Transplantation | pt_BR |
Subject | Zika virus | pt_BR |
Peer reviewed | Não | pt_BR |
Publication status | Não Publicado | pt_BR |