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Autor | Cavalcanti, Amanda | |
Autor | Lobo, Rogério | |
Autor | Cupolillo, Elisa | |
Autor | Bustamante, Fábio | |
Autor | Porrozzi, Renato | |
Fecha de acceso | 2017-04-18T13:03:36Z | |
Fecha de disponibilización | 2017-04-18T13:03:36Z | |
Fecha de publicación | 2012 | |
Referencia | CAVALCANTI, Amanda; et al. Canine cutaneous leishmaniasis caused by neotropical Leishmania infantum despite of systemic disease: A case report. Parasitology International, v.61, n.4, p.738-740, Dec. 2012. | pt_BR |
ISSN | 1383-5769 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18478 | |
Idioma | eng | pt_BR |
Editor | Elsevier | pt_BR |
Derechos de autor | restricted access | pt_BR |
Palabras clave en Portugués | Leishmania infantum | pt_BR |
Palabras clave en Portugués | Ferimentos crônicos | pt_BR |
Palabras clave en Portugués | Leishmaniose canina | pt_BR |
Título | Canine cutaneous leishmaniasis caused by neotropical Leishmania infantum despite of systemic disease: A case report | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1016/j.parint.2012.05.002 | |
Resumen en Inglés | Visceral leishmaniasis is an anthropozoonosis caused by a protozoan Leishmania infantum (syn. Leishmania chagasi). Here, we report a typical case of canine cutaneous leishmaniasis due to L. infantum infection without any other systemic symptom in one dog in the city of Rio de Janeiro, Brazil. A mongrel female dog was admitted in a veterinary clinic with reports of chronic wounds in the body. Physical examination revealed erosive lesions in the limbs, nasal ulcers, presence of ectoparasites and seborrheic dermatitis. Blood samples and fragments of healthy and injured skin were collected. The complete hemogram revealed aregenerative normocytic normochromic anemia and erythrocyte rouleaux, and biochemical analysis revealed normal renal and hepatic functions. Cytology of the muzzle and skin lesions suggested pyogranulomatous inflammatory process. The histopathology of a skin fragment was performed and revealed suspicion of protozoa accompanied by necrotizing dermatitis. The diagnosis of leishmaniasis was accomplished by positive serology, isolation of Leishmania from the skin lesion, and also by molecular test (PCR targeting the conserved region of Leishmania kDNA). Culture was positive for damaged skin samples. PCR targeting a fragment of Leishmania hsp70 gene was performed employing DNA extracted from damaged skin. RFLP of the amplified hsp70 fragment identified the parasite as L. infantum, instead of Leishmania braziliensis, the main agent of cutaneous leishmaniasis in Rio de Janeiro. Characterization of isolated promastigotes by five different enzymatic systems confirmed the species identification of the etiological agent. Serology was positive by ELISA and rapid test. This case warns to the suspicion of viscerotropic Leishmania in cases of chronic skin lesions and brings the discussion of the mechanisms involved in the parasite tissue tropism. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Veterinários Clínicos Autônomos. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Afiliación | Veterinários Clínicos Autônomos. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil. | pt_BR |
Palavras clave en Inglês | Canine leishmaniasis | pt_BR |
Palavras clave en Inglês | Leishmania infantum | pt_BR |
Palavras clave en Inglês | Chronic wounds | pt_BR |
Fecha de embargo | 2030-01-01 |
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