Author | Gandra, Paulo Guimaraes | |
Author | Valente, Richard Hemmi | |
Author | Perales, Jonas | |
Author | Pacheco, Antonio Guilherme Fonseca | |
Author | Macedo, Denise Vaz | |
Access date | 2017-05-04T14:55:22Z | |
Available date | 2017-05-04T14:55:22Z | |
Document date | 2012 | |
Citation | GANDRA, Paulo Guimarães; et al. Proteomic profiling of skeletal muscle in an animal model of overtraining.Proteomics, v.12, p.2663-2667, 2012. | pt_BR |
ISSN | 1615-9853 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18753 | |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Proteómica animal | pt_BR |
Subject in Portuguese | Defesa antioxidante | pt_BR |
Subject in Portuguese | Exercício | pt_BR |
Subject in Portuguese | Músculo gastrocnêmio | pt_BR |
Subject in Portuguese | Capacidade oxidativa | pt_BR |
Title | Proteomic profiling of skeletal muscle in an animal model of overtraining | pt_BR |
Type | Article | pt_BR |
DOI | 10.1002/pmic.201200137 | |
Abstract | Excessive training (i.e. overtraining, OT) may result in underperformance, which can be characterized by the time needed to re-establish performance (i.e. functional overreaching (FOR), nonfunctional overreaching, OT syndrome). The present study is an initial screening for proteins presenting altered abundance in the red (RG) and white (WG) portions of the gastrocnemius muscle from rats submitted to an OT protocol that induced FOR. In the RG, compared to the nontrained control, FOR demonstrated an increased abundance of proteins normally related to adaptation to endurance training (e.g. proteins of oxidative phosphorylation complexes, proteins related to lipid metabolism, antioxidants, and chaperones). In the WG, spots identified as mitochondrial aconitase and a component of the succinate dehydrogenase complex were downregulated in FOR, as were proteins related to myofibril stabilization; these latter were upregulated in the RG. This initial study shows that skeletal muscles with different fiber-type compositions respond differently to an OT period. Also, it is likely that actin-interacting proteins have an important role in muscle adaptation to endurance exercise. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Laboratório de Bioquímica do Exercício. Campinas, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Campinas. Laboratório de Bioquímica do Exercício. Campinas, SP, Brasil. | pt_BR |
Subject | Animal proteomics | pt_BR |
Subject | Antioxidant defense | pt_BR |
Subject | Exercise | pt_BR |
Subject | Fiber-type | pt_BR |
Subject | Gastrocnemius muscle | pt_BR |
Subject | Oxidative capacity | pt_BR |
e-ISSN | 1615-9861 | |
Embargo date | 2030-01-01 | |